子宫肌瘤MRI影像非刚性配准研究  

Research on Non-rigid Registration in Uterine Fibroids MR Imaging

作　　者：所世腾[1] 张良宾[1] 李跃华[2] 陈亚珠[1,3] 张素[1] 

机构地区：[1]上海交通大学 [2]上海交通大学附属第六人民医院 [3]中国工程院

出　　处：《微型电脑应用》2012年第12期1-4,共4页Microcomputer Applications

基　　金：国家基础研究发展计划(973项目:2010CB732506;国家自然科学基金(60972110)

摘　　要：高强度聚焦超声(High-Intensity Focused Ultrasound,HIFU)治疗和磁共振技术结合(MRI-guided HIFU,MRgHIFU)采用MRI进行目标定位、治疗规划和能量沉积的闭环控制以保障热消融不伤及周围组织,其中图像配准是校正定位误差,实施精确治疗的重要环节。针对三维非刚性配准方法,在子宫肌瘤的治疗计划修正和跟踪方面的应用进行研究。针对前后两个不同时段采集的子宫肌瘤MR影像,分别进行基于自由形变模型(Free-From Deformation,FFD)算法和Demons算法的非刚性配准对比。实验结果表明,该基于FFD的非刚性配准算法,对于形变较小的子宫肌瘤真实数据能够取得较为合适的配准效果,重叠区域的互相关系数(CC)从配准前的0.59提高到配准后的0.74。High-Intensity Focused Ultrasound （HIFU） combined with magnetic resonance achieves thermal ablation without hurting the surrounding tissue through a closed-loop control process of target positioning and treatment planning. Image registration is a vital important section in correction of positioning error and implement of precise treatment. Research of non-rigid registration in amend- ments and tracing of treatment plan was carried out, in which series of uterine fibroids MR images acquired in two different times are employed as experimental data. Then non-rigid registration based on Free-Form Deformation and Demons were performed succes- sively for a comparison of the results. The experiments shows that the FFD based registration achieved preferable results with tiny deformation, and the correlation coefficient （CC） of overlapping region increased from 0.59 to 0.74 after registration.

关 键 词：子宫肌瘤 磁共振成像(MRI) 图像非刚性配准 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]