黏质沙雷菌对碳青霉烯类抗生素的耐药性研究  

Study on carbapenem resistance characterization of Serratia marcescens

作　　者：邹安庆[1] 费静娴 吴莲凤[1] 谢瑶瑶[1] 周铁丽[1] 

机构地区：[1]温州医学院附属第一医院实验诊断中心,温州325000 [2]湖州市中心血站,湖州313000

出　　处：《中国抗生素杂志》2013年第1期59-62,共4页Chinese Journal of Antibiotics

基　　金：浙江省卫生厅资助项目(2011KYA106)

摘　　要：目的了解黏质沙雷菌的临床感染特点和耐药现状,分析其对碳青霉烯类抗生素的耐药特性。方法回顾性调查2004年—2010年临床分离109株黏质沙雷菌的分布情况,VITEK-60自动化微生物分析仪检测其对临床常用抗菌药物的敏感性,琼脂稀释法测定其对亚胺培南、美罗培南和厄他培南的最低抑菌浓度(MIC)。结果临床分离黏质沙雷菌各年份分离数呈上升趋势。标本来源以痰液标本最多,占73.4%,其次为尿液标本,占12.8%、血液标本,占6.4%;黏质沙雷菌对环丙沙星、复方磺胺甲噁唑、阿米卡星、左氧氟沙星、头孢曲松的敏感率均大于80%,对亚胺培南、美罗培南、厄他培南3种碳青霉烯类抗生素的耐药率分别为8.3%,5.5%和22.0%。结论临床分离的黏质沙雷菌对抗菌药物的总体敏感性较好,但出现较高比例的碳青霉烯类抗生素耐药株,且不同种类碳青霉烯类药物的耐药性存在差异。Objective To investigate the clinical infection and drug resistance in Serratia marcescens, and analysis its resistance characteristics to carbapenems antibiotic. Methods Retrospective survey the distribution of 109 Serratia marcescens clinical isolated from 2004 to 2010, VITEK-60 automatic microorganism analyzer was used to detect the susceptibility of antibiotics, and minimum inhibitory concentration （MIC） of imipenem, meropenem and ertapenem were detected by agar dilution method. Results The number of Serratia marcescens strains isolated had a upward trend year after year. And the specimen which was from the sputum occupy the most, accounting for 73.4%, followed by urine 12.8% and blood 6.4%; The sensitivity rates of ciprofloxacin, sulfamethoxazole, amikacin, levofloxacin and ceftriaxone were all above 80%, the resistance rates were 8.3% （9/109）, 5.5% （6/109） and 22.0% （24/109） to imipenem, meropenem, ertapenem respectively. Conclusion Clinical isolates ofSerratia marcescens has a fine overall sensitivity to antimicrobial drugs, but there is a high proportion of carbapenem antibiotics resistant, and there is a discrepancy in different carbapenem antibiotics.

关 键 词：黏质沙雷菌 碳青霉烯类 耐药性 MIC 

分 类 号：R978.11[医药卫生—药品]