谱效关系在中药研究中的应用及相关思考  

Application of spectrum-effect relationship in Chinese medicine research and related thinking

作　　者：秦昆明[1,2,3] 郑礼娟[1] 沈保家[1] 张星海[1] 李嬛[1,2] 狄留庆[1,3] 徐自升 蔡宝昌[1,2,3] 

机构地区：[1]南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心,江苏南京210029 [2]南京海昌中药集团有限公司,江苏南京210061 [3]国家中医药管理局中药炮制标准重点研究室,江苏南京210046

出　　处：《中国中药杂志》2013年第1期26-31,共6页China Journal of Chinese Materia Medica

基　　金：江苏省自然科学基金项目(BK2011135);江苏省企业博士集聚计划项目;江苏省高校优势学科项目(ysxk-2010);南京中医药大学中药学一级学科开放课题项目(2011ZYX2-013)

摘　　要：指纹图谱技术是现代中药研究的关键技术之一,谱效关系研究是指纹图谱研究的高级阶段,通过对指纹图谱和药效作用进行分析,揭示指纹图谱和药效作用的相关性,进而应用于中药研究。谱效关系在中药研究中具有多方面的应用,包括单味药和复方药效物质研究、组分配伍研究、炮制机制研究、药效作用预测研究以及工艺优化研究等。该文对谱效关系在中药研究中的应用进行了系统综述,指出了目前谱效关系研究中需要注意的几个问题,并且展望了谱效关系的研究前景。Fingerprint technology is the key technology in modern Chinese medicine research, while spectrum-effect relation- ship research is the advanced stage of fingerprint research. Spectrum-effect relationship research can reveal the relationship between fingerprint and pharmacological effect through multiple statistical analyses, which can be used in Chinese medicine research. Spectrum- effect relationship has been used in many areas of Chinese medicine research, such as effective basis of single and compound Chinese medicine research, component compatibility research, processing mechanism research, pharmacological effect forecast research, tech- nology optimization research, and so on. This paper systematically reviewed the application of spectrum-effect relationship in Chinese medicine research, and indicated some problems in spectrum-effect relationship research. At last, the authors give an outlook of the fu- ture of spectrum-effect relationship research.

关 键 词：谱效关系 中药 指纹图谱 

分 类 号：R284[医药卫生—中药学]