糖尿病肾病大鼠糖代谢调节激素改变及六味地黄丸对其的影响  

Effect of LiuWeiDiHuangWan on the Changes of Hormone for Glucose Metabolism Regulation in Diabetic Nephropathy Rats

作　　者：韦道明[1] 朱雪红[1] 郑士荣[1] 朱宇清 蔡淦[3] 

机构地区：[1]解放军第85医院,上海200052 [2]上海市临床检验中心,上海200126 [3]上海中医药大学附属曙光医院,上海200021

出　　处：《深圳中西医结合杂志》2012年第6期333-335,345,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市医学发展基金(05Ⅱ010)

摘　　要：目的:探讨糖尿病肾病大鼠糖代谢调节激素改变及六味地黄丸对其的影响。方法:用链脲霉素建立糖尿病肾病大鼠模型,六味地黄丸治疗8周后,检测血糖、尿微量白蛋白含量、尿β微球蛋白含量、血清胰岛素、血浆胰高血糖2素、血清及垂体生长激素水平等指标。结果:六味地黄丸治疗组空腹血糖显著降低,血浆胰高血糖素降低;尿微量白蛋白含量、尿β微球蛋白含量降低;垂体生长激素水平下降。结论:六味地黄丸有调控糖代谢调节激素,保护肾功能等作2用。Objective To investigate the effect of LiuWeiDiHuangWan （LWDHW） on the changes of regulatory hormone for glucose metabolism in diabetic nephropathy rats. Methods Diabetic nephropathy rat model was established by using Streptozotocin. After the rats were treated with LWDHW for 8 weeks, the blood glucose level, the contents of urinary microalbumin and urinary β2 microglobulin （β2-MG）, the levels of serum insulin, plasma glucagon and growth hormone in serum and pituitary were all measured. Results Compared with the control group, the levels of fasting blood glucose and plasma pancreatic glucagon in LWDHW treatment group were significantly lowered. The contents of urinary albumin and urinary β2-MG were decreased. The pituitary growth hormone level was descended. Conclusion LWDHW could play the role of regulating the levels of regulatory hormones for glucose metabolism and protecting renal function.

关 键 词：六味地黄丸 糖尿病肾病 糖代谢 调节激素 

分 类 号：R587.2[医药卫生—内分泌]