PPARα在器官移植中的作用初探  

Effects of PPARα on Organ Transplantation

作　　者：张元元[1] 李耀康[1] 王敏[1] 尹红春[1] 王光明[1] 

机构地区：[1]大理学院临床医学院,云南大理671000

出　　处：《大理学院学报（综合版）》2012年第12期10-12,共3页Journal of Dali University

摘　　要：目的:探讨PPARα在器官移植中的作用。方法:C57BL/6J经口给予非诺贝特或者Wy14643,连续7 d,取脾脏,同时取BALB/c小鼠的脾脏,分离脾细胞进行混合淋巴细胞反应。结果:经过非诺贝特或者Wy14643处理的小鼠,其脾细胞在混合淋巴细胞反应中表现为无应答。结论:非诺贝特或者Wy14643激活的PPARα具有抑制混合淋巴细胞反应的作用。Objective： To investigate the effect of PPARα on organ transplantation on mice model. Methods： Fenofibrate, Wy14643, or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J, spleen from C57BL/6J or BALB/c was collected and splenoeyte was isolated. Mixed lymphocyte reaction （MLR） was carried out. Results： The splenocyte was no response in MLR from the mice treated with fenofibrate, or Wy14643. Conclusion： PPARα could be activated by fenofibrate, or Wy14643, could inhibit MLR.

关 键 词：器官移植 PPARΑ 非诺贝特 WY14643 

分 类 号：S857.13[农业科学—临床兽医学] R617[农业科学—兽医学]