模拟移动床改进进料模式实验研究  

Experimental study on a modified feeding mode of simulated moving bed

作　　者：陈明杰[1] 沈波[1] 危凤[1] 

机构地区：[1]浙江大学宁波理工学院生物与化学工程分院,浙江宁波315100

出　　处：《化学工业与工程技术》2012年第6期7-10,共4页Journal of Chemical Industry & Engineering

基　　金：宁波市自然科学基金(2009A610153);宁波市生物医药人才培养基地建设项目(Jd090222)

摘　　要：常规的模拟移动床色谱II区流出液与原料液在线混合进入III区,会导致进料浓度的降低,从而影响模拟移动床的生产效率。而新的进料模式,将II、III区断开,定期收集II区流出液,在II区流出液中溶解一定量的原料,使其浓度与初始进料浓度相等,然后在下一个周期中作为原料进到III区。以α-生育酚的制备为研究对象,对模拟移动床新型进料模式和传统进料模式进行对比,结果表明,新型进料模式比传统进料模式生产效率提高了53.04%,溶剂消耗减少了35%。同时,在新型进料模式下α-生育酚在SMB系统内部的最高浓度提高了77.24%,而非α-生育酚在SMB系统内部的最高浓度提高了67.31%。在改进进料模式下,α-生育酚的生产能力得到了提高。The feeding concentration of the conventional simulated moving bed （SMB） is diluted by mixing the outlet stream of zone Ⅱ with raw material fluid into zone Ⅲ, which will reduce the productivity of SMB. A new feeding mode for a simulated moving bed is proposed that zone Ⅱ and zoneⅢ is separated. The outlet stream from zone Ⅱ is collected at regular intervals, and the concentration of the solution is increased to the initial concentration by dissolving raw materials and then fed to zone Ⅲ as the feed stream during the next collection interval. Using α-tocopherol as experimentation object, the traditional feeding mode and the new feeding mode is com- pared. The results show that under the mew feeding mode, the productivity increases by 53.04% and the solvent consumption decrea- ses by 35%. The maximum concentration of α-tocopherol and non-α-tocopherol in SMB systern increases by 77.24 % and 67.31% respectively. The production capacity of a-tocopherol enhances under the modified feeding mode.

关 键 词：模拟移动床 改进进料模式 实验研究 

分 类 号：TQ028.8[化学工程]