出 处:《中华儿科杂志》2013年第1期4-11,共8页Chinese Journal of Pediatrics
基 金:2011年广东省第三批科技计划项目(2011-97);广州市医药卫生科技项目(201102A213149);广州市科技计划项目应用基础研究专项重点项目(2011J4100046)
摘 要:目的研究极低出生体重儿(VLBWI)住院期间的生长发育状态及相关影响因素。方法回顾性调查广东省珠江三角洲地区9个城市的9家医院新生儿科于2010年7月1日至2011年6月30日,出院的VLBWI的住院资料,根据出生体重,分为宫内生长发育迟缓[IUGR组(n=63)]和非IUGR组(n=120),非IUGR组又根据其出院时是否发展为宫外生长发育迟缓(EUGR)而分为EUGR组(n=71)和非EUGR组(n=49),对比性研究IUGR组和非IUGtl组住院期间的日均体重增长速度和出院时EUGR的发生率,及各组的院内营养摄入情况、生长速度和相关疾病因素的影响。结果(1)出生时IUGR和出院时EUGR的发生率分别为34.4%和72.1%,IUGR组的日均体重增长速度高于非IUGR组[(12.5±2.7)g/k vs(11.3±2.5)g/kg,t=3.068,P=0.002],但IUGt/组发展为EUGR的比例明显高于非IUGR组(96.8%vs59.2%,X^2=29.145,P=0.000)。(2)IUGR组在生后1、2、4周、达完全经口喂养前和住院期间的日均热卡摄入[62(51,69)kcal/kg vs 56(45,64)kcal/kg、83(71,94)keal/kg vs 76(66,88)keal/kg、107(94,120)keal/kg vs 95(85,108)kcal/kg;103(96,110)keal/kg vs 97(89,106)kcal/kg、121(111,131)keal/kg vs 111(101,119)kcal/kg](1kcal=4.1840kJ)。蛋白质摄入[1.7(1.3,2.0)g/kg vs 1.6(1.2,1.8)g/kg、2.6(2.1,2.9)g/kg vs 2.3(1.9,2.7)g/kg、3.3(2.7,3.6)g/kg vs 2.7(2.4,3.2)g/kg、3.1(2.6,3.4)g/kg vs 2.8(2.4,3.3)g/k、3.4(3.1,3.8)g/kg vs 3.1(2.8,3.5)g/k]均高于非IUGR组(P〈0.05)。热卡累积损失[407(360,483)kca]/kg vs 448(393,527)keal/kg、534(369,689)kcal/kgw612(453,758)keal/kg、367(12,724)kcal/kg vs 718(330,996)kcal/kg、381(231,609)kcal/kg vs 656(394,959)keal�Objective To study the postnatal growth of very low birth weight infant (VLBWI) and its relevant influencing factors during hospitalization. Method Clinical data of very low birth weight infants (VLBWI) ,who were discharged from July 1 st ,2010 to June 30th ,2011, were collected retrospectively from 9 NICUs of 9 cities in Pearl River Delta, Guangdong province. A total of 183 cases of VLBW premature infants were enrolled in this research. The incidence of intrauterine growth retardation (IUGR) at birth and extrauterine growth retardation (EUGR) on discharge were assessed. According to IUGR at birth, they were assigned into two groups: IUGR group (n = 63 ) and non-IUGR group (n = 120). And non-IUGR group were further assigned into EUGR group (n = 71 ) and non-EUGR group (n = 49 ). The mean daily growth rate during hospitalization and the incidence of EUGR on discharge were studied comparatively to IUGR group and non-IUGR group. The nutrition intake, mean growth rate and relevant illnesses were studied comparatively to IUGR group and non-IUGR group , EUGR group and non-EUGR group. Result ( 1 ) The incidence of IUGR at birth was 34.4% ,while the incidence of EUGR on discharge was 72. 1%. The mean daily growth rate to body weight of IUGR group was higher than that of non-IUGR groupE ( 12. 5 ± 2. 7 ) g/kg vs ( 11.3 ± 2. 5 ) g/kg, P = 0. 0021. The increasing incidence from IUGR to EUGR, IUGR group was higher than non-IUGR group (96. 8% vs 59. 2% ,P =0. 000). (2) The mean daily energy and protein intake in postnatal time of 1 weekE62(51,69) kcal/kg vs 56(45,64) kcal/kg( 1 kcal -4. 1840 kJ),1.7( 1.3,2. 0) g/kg vs 1.6 ( 1.2,1.8 ) g/kgl, 2 weeks E 83 (71,94) kcal/kg vs 76 ( 66,88 ) kcal/kg, 2. 6 ( 2. 1,2. 9 ) g/kg vs 2. 3 (1.9,2.7) g/kg], 4 weeksI107(94,120) keal/kgvs95(85,108) kcal/kg,3.3(2.7,3.6) g/kgvs 2.7 (2. 4,3.2) g/kg], before total enteral nutritionE 103(96,110) kcal/kg vs 97(89,106) keal/kg,3. 1 (2.
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