吸入糖皮质激素佐治咳嗽变异性哮喘的疗效评估  

Efficacy evaluation of the inhalation of glucocorticoid in the treatment of patients with cough variant asthma

作　　者：陶莹[1] 赵鑫梅 石李金 许敏[1] 詹鑫亮 

机构地区：[1]黄梅县人民医院呼吸内科,湖北黄冈435500

出　　处：《临床肺科杂志》2013年第2期276-277,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨吸入布地奈德干粉吸入剂佐治咳嗽变异性哮喘的临床价值。方法将2011年03月～2012年03月本院诊治的90例咳嗽变异性哮喘患者随机分成两组:实验组45例,对照组45例。对照组采用异丙托溴铵气雾剂+常规基础治疗;实验组则再给予布地奈德干粉吸入剂辅助治疗。观察比较两组的临床疗效、住院时间、哮喘症状评分、症状改善时间、肺功能。结果实验组的总有效率明显高于对照组(P<0.05);实验组患者的住院时间明显短于对照组(P<0.05);实验组患者的哮喘症状评分明显低于对照组(P<0.05);实验组患者气喘缓解、咳嗽消失、哮鸣音消退等症状改善时间均明显短于对照组(P<0.05);实验组患者治疗后的FEV1、FVC、FEV1/FVC、PEF、FEF25等肺功能指标水平明显优于对照组(P<0.05)。结论吸入布地奈德干粉吸入剂佐治咳嗽变异性哮喘的临床疗效显著。Objective To evaluate the clinical effect of the inhalation of budesonide dry powder in the treatment of patients with cough variant asthma. Methods 90 patients with cough variant asthma were randomly and evenly divided into two groups. The control group were given ipratropium bromide aerosol and the conventional treatment, and the treatment group were given budesonide dry powder inhaler on the basis of the control group. The clinical effects, the duration of hospital stay, the scores of asthma symptom, the time of symptoms disappeared, and the lung function were observed and compared between the two groups. Results The total effective rate was significantly higher in the treatment group than in the control group （ P 〈 0. 05 ）. The symptom scores were significantly lower in the treat- ment group than in the control group （ P 〈 0. 05 ）. The duration of hospital stay and the time of symptoms disappeared in the treatment group were significantly shorter than that in the control group （ P 〈0. 05 ）. The index values of FEV1 , FVC, FEV1/FVC, PEF and FEF25 in the treatment group were better improved than those in the control group （P 〈0. 05）. Conclusion The inhalation of budesonide dry powder has a favorable effect in the treatment of patients with cough variant asthma.

关 键 词：咳嗽变异型哮喘 异丙托溴铵气雾剂 布地奈德干粉吸入剂 

分 类 号：R562.25[医药卫生—呼吸系统]