N-乙酰半胱氨酸辅助治疗肺结核患者氧化/抗氧化失衡的影响  

The effect on the imbalance between oxidantion and anti-oxidantion of N-acetylcysteine adjunctive therapy for pulmonary tuberculosis

作　　者：梁清涛[1] 李琦[1] 古淑香[1] 贾红艳[1] 张宗德[1] 

机构地区：[1]首都医科大学附属北京胸科医院结核三科,北京101149

出　　处：《临床肺科杂志》2013年第2期306-307,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨N-乙酰半胱氨酸(NAC)辅助治疗对肺结核患者氧化抗氧化失衡的影响。方法测定20例肺结核患者在予以N-乙酰半胱氨酸治疗前后血清的谷胱甘肽过氧化物酶(GPX)、超氧化物歧化酶(SOD)、丙二醛(MDA)。结果在应用N-乙酰半胱氨酸后,患者的SOD、GPX增高(P<0.05),而MDA没有统计学变化。结论 N-乙酰半胱氨酸与抗结核药物联合应用,可改善肺结核患者的氧化/抗氧化失衡。Objective The study on the imbalance between oxidantion and anti-oxidantion of N-acetylcysteine（NAC） adjunctive therapy for pulmonary tuberculosis. Methods Before and after they had been given NAC treatment, the glutathione peroxidase （GPX） . superoxide dismutase（SOD） and malonaldebyde（MDA） were detected in the sera of 20 patients with pulmonary tuberculosis. Results After they were treated with NAC, the levels of GPX ,SOD increased in the patients with tuberculosis （P 〈 0.05 ） , MDA did not change. Conclusion Combine using NAC with anti-tuberculosis medicine could improve the imbalance between oxidantion and anti-oxidantion.

关 键 词：肺结核 乙酰半胱氨酸 氧化 抗氧化 

分 类 号：R521[医药卫生—内科学]