索利那新联合坦索罗辛治疗经尿道前列腺电切术术后膀胱过度活动症  

Preliminary study of Solifenacin and Tamsulosin for the treatment of overactive bladder symptoms after transurethral resection of prostate

作　　者：于洪波[1] 林建中[1] 吴宏飞[1] 周鹤同[1] 沈华[1] 张斌[1] 李久明[1] 

机构地区：[1]南京医科大学南京明基医院泌尿外科,江苏南京210019

出　　处：《现代泌尿外科杂志》2013年第1期52-55,共4页Journal of Modern Urology

摘　　要：目的探讨索利那新联合盐酸坦索罗辛预防性治疗经尿道前列腺电切术(TURP)后膀胱过度活动症的疗效。方法收集84例良性前列腺增生症患者的基本资料,发病年龄52～90(72.3±6.4)岁,随机分为4组:联合药物组、索利那新组、坦索罗辛组及对照组各21例。比较各组TURP术后3d内膀胱区阵发性痉挛性疼痛的次数、膀胱痉挛持续时间及拔管后第1天和第3天尿频、尿急的情况。结果各组在术后3d内膀胱痉挛次数、膀胱痉挛平均持续时间均少于对照组(P<0.05);索利那新组术后第2、第3天膀胱痉挛次数分别为(1.64±0.42)次和(1.28±0.65)次,膀胱痉挛平均持续时间分别为(0.19±0.18)h和(0.20±0.07)h,少于盐酸坦索罗辛组(3.03±0.28)次和(2.18±0.58)次、(0.28±0.15)h和(0.23±0.11)h。联合药物组膀胱痉挛次数(1.33±0.31)次和(0.88±0.21)次,其持续时间为(0.18±0.11)h和(0.15±0.10)h,少于索利那新组(P<0.05)。拔管后第1、3天,索利那新联合坦索罗辛组患者的尿频、尿急次数明显低于索利那新组和盐酸坦索罗辛组(P<0.05)。结论早期预防性联合应用索利那新与坦索罗辛可能是一种安全有效的缓解患者TURP术后膀胱过度活动症的方法,有助于患者的术后恢复和生活质量的提高。Objective To evaluate the efficacy of Solifenacin and Tamsulosin for the treatment of overactive bladder （OAB） after transurethral resection of prostate （TURP）. Methods From Aug. 2008 to June 2010, a total of 84 patients with benign prostate hyperplasia （BPH） were treated with TURP. The average age of the patients was 72.3±6.4. All patients were randomly divided into 4 groups, including Solifenacin and Tamsulosin group, Solifenacin group, Tamsulosin group, and the control group, The number and duration of paroxysmal spasms, urinary frequency and urgency were recorded after the catheter was removed. Results The average number and duration of bladder spasms in all treatment groups were fewer or shorter than those of the control group on the second and third day after TURP. The number and duration of bladder spasms were the fewest or shortest in the Solifenacin and Tamsulosin group, then the Solifenacin group, and then the Tamsulosin group （P〈0.05）. Urinary frequency and urgency in the Solifenacin and Tamsulosin group was significantly fewer than those in the other groups （P〈0.05）. Conclusion Combination of Solifenacin with Tamsulosin may be safe and effective for the treatment of OAB after TURP, and helpful for the recovery of the patients.

关 键 词：索利那新 坦索罗辛 前列腺增生 经尿道前列腺电切术 膀胱过度活动症 

分 类 号：R694.2[医药卫生—泌尿科学]