农村地区自杀死亡与遗传因素的关系  

Completed suicide and genetic factors in rural suicides

作　　者：胡霞[1] 贾存显[1] 王琳琳[1] 廉颖[1] 韩梅[1] 刘慧[1] 

机构地区：[1]山东大学公共卫生学院流行病与卫生统计学研究所,济南250012

出　　处：《中国心理卫生杂志》2013年第1期23-27,共5页Chinese Mental Health Journal

基　　金：山东省博士后创新项目(200703091);国家自然科学基金(30972527)

摘　　要：目的:探讨农村自杀死亡与遗传因素的关系及不同特征一级亲属自杀遗传度的大小,为制定农村自杀的预防对策与措施提供依据。方法:在山东省疾病监测点上选取自杀死亡者153例,对照组153例,通过问卷调查获取他们的一级亲属资料,通过1:1配对病例对照研究对他们及其一级亲属资料进行遗传流行病学研究,采用Penrose法估计遗传模式,Falconer回归法估算遗传度。结果:自杀家族史与自杀死亡高度相关(OR=13.25)。一级亲属自杀遗传度(h^2)为(34.0±6.4)%;≥60岁者的自杀遗传度为(51.2±7.0)%,<60岁者(14.8±11.8)%;女性(23.2±10.2)%,男性(46.7±7.6)%;无精神障碍者(31.7±7.1)%,有精神障碍者(42.1±13.1)%;非暴力方式者(39.2±7.8)%,暴力方式者(25.4±10.7)%;低自杀意图者(21.6±13.6)%,高自杀意图者(38.1±7.1)%。结论:在农村自杀死亡者中,遗传因素可能是重要的危险因素,在较高年龄、男性、有精神障碍、非暴力方式、高自杀意图的自杀死亡者中遗传因素可能起更大的作用。Objective： To explore the relationship between completed suicides and genetic factors in rural areas, estimate the heritability for first-level relatives of suicides, and then provide scientific evidence for its prevention and control. Methods： Totally 153 completed suicides and 153 controls were enrolled from Shandong Disease Surveillance Points. A 1 to 1 case-control study was performed to obtain data of completed suicides and their first-level relatives by method of questionnaire for genetic epidemiology study. Penrose method was used to estimate heredity followed by using Falconer method applied to estimate the effects of heritability. Results： Family history of suicide was considered to be highly associated with completed suicides with OR of 13.25. Heritability for first-level relatives of suicides （h2） was （34. 0± 6.4） %. The h2 were （51.2 ± 7. 0） % for ones aged 60 years or older （ 14. 8 ± 11.8） % for those aged less than 60 years old, （23.2 ± 10. 2）% for females, （46. 7 ±7. 6）% for males, （42. 1 ± 13.1） % for ones with mental illness, （31.7 ± 7.1） % for ones without mental illness, （25.4 ± 10. 7） % for ones with violent behaviors, （39. 2 ± 7.8） % for ones without violent behaviors, （38. 1 ± 7. 1） % for ones with higher intent to commit suicide, and （21.6± 13.6） % for ones with lower intent. Conclusion： It suggests that genetic factors may be the important risk factors in the rural suicides, especially in males and those with older age, mental illness history and high intent to commit suicide, and those without violent behaviors.

关 键 词：自杀 农村 遗传度 危险因素 心理解剖 

分 类 号：C913.9[经济管理]