不同灸时温和灸对急性高脂血症大鼠施灸局部缝隙连接蛋白43表达的影响  

Effect of Warming Moxibustion for Different Time on Connexin 43 Expression in Moxibustion Focus of Acute Hyperlipemia Rats

作　　者：王耀帅[1] 王士超[1] 张建斌[1] 徐斌[1] 王玲玲[1] 

机构地区：[1]南京中医药大学第二临床医学院,江苏南京210046

出　　处：《广州中医药大学学报》2013年第1期44-46,129,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973)项目(编号:2009CB522905)

摘　　要：【目的】探讨不同灸时温和灸对急性高脂血症大鼠施灸局部缝隙连接蛋白43(Cx43)表达的影响。【方法】选用SD大鼠,随机分为模型对照组,温和灸5、10、15 min组;建立急性高脂血症大鼠模型,观察5、10、15 min 3种灸时的温和灸刺激对大鼠施灸局部神阙穴皮肤Cx43表达的影响。【结果】温和灸各治疗组均可增加Cx43的表达,与模型对照组比较差异有统计学意义(P<0.01),温和灸10 min组、温和灸15 min组增加值较温和灸5 min组显著,差异有统计学意义(P<0.05),温和灸10 min组与温和灸15 min组比较差异无统计学意义(P>0.05)。【结论】温和灸对高脂血症的治疗作用与其能调节Cx43表达有关。Objective To investigate the influence of warming moxibustion for different time on connexin 43（Cx43） expression in moxibustion focus of acute hyperlipemia rats.Methods SD rats were randomized into model group,and three warming moxibustion groups（treated with warming moxibusion for 5,10,15 min,respectively）.Acute hyperlipemia rat model was established for the observation of Cx43 expression in the rat local skin of acupoint Shenque after warming moxibustion for different time.Results Cx43 expression level was increased in warming moxibustion groups,and the difference was significant compared to the model group（P〈0.01）.Cx43 expression level in 10-min warming moxibustion group and 15-min warming moxibustion group differed from that in 5-min warming moxibustion group（P〈0.05）,but the difference between 10-min warming moxibustion group and 15-min warming moxibustion group was not significant（P〉0.05）.Conclusion Warming moxibustion is effective for the treatment of hyperlipemia,and the therapeutic mechanism is related to the regulation of Cx43 expression.

关 键 词：温和灸 治疗应用 高脂血症 针灸疗法 皮肤 病理学 疾病模型 动物 大鼠 

分 类 号：R245.81[医药卫生—针灸推拿学]