喷他脒的合成工艺探究  

Process Research on the Synthesis of Pentamidine

作　　者：谢光益[1] 曾国勇[1] 

机构地区：[1]丽水学院理学院,浙江丽水323000

出　　处：《广州化工》2013年第2期62-64,共3页GuangZhou Chemical Industry

摘　　要：探究了喷他脒的合成工艺路线,以对羟基苯腈和1,5-二溴戊烷为起始原料合成了1,5-二-(4-氰基苯氧基)戊烷(Ⅰ);Ⅰ与干燥的氯化氢气体加成制得1,5-二-[4-(甲亚胺酸甲酯)苯氧基]戊烷盐酸盐(Ⅱ);Ⅱ的甲醇溶液中通入氨气,氨解合成了喷他脒(Ⅲ),总收率42.1%,其结构经1HNMR表征。The pentamidine synthesis process route was explored,Pentamidine（Ⅲ） in total yield of 42.1% was synthesized in methanol ammonia by ammonolysis of dimethyl 4,4＇-（pentane-1,5-diylbis（oxy））dibenzimidate dihydrochloride which was prepared using dry hydrogen chloride gas addition of 1,5-bis（4-cyanophenoxy） pentane produced by the reaction of p-hydroxybenzonitrile with 1,5-dibromopentane.The structure of Ⅲ was confirmed by1H NMR.

关 键 词：喷他脒 对羟基苯腈 氨解 药物合成 

分 类 号：TQ463[化学工程—制药化工]