超低体重婴儿医院感染的临床分析  

Clinical analysis of nosocomial infections in extremely low birth weight infants

作　　者：汪盈[1] 李海静[1] 杨祖钦[1] 林振浪[1] 

机构地区：[1]温州医学院附属育英儿童医院新生儿科,浙江温州325027

出　　处：《中华医院感染学杂志》2013年第2期385-387,共3页Chinese Journal of Nosocomiology

基　　金：温州市科技计划项目(Y20100248)

摘　　要：目的了解超低体重婴儿医院感染的发生、病原菌分布及药敏性,为有效控制超低出生体重儿医院感染提供依据。方法对2006年7月-2011年6月医院新生儿ICU中发生医院感染的70例超低出生体重儿进行回顾性分析。结果超低出生体重儿医院感染主要以肺炎和败血症为主;共检出病原菌104株,革兰阴性菌66株占63.5%,革兰阳性菌28株占26.9%;革兰阴性杆菌以肺炎克雷伯菌最常见,产ESBLs菌株达100.0%,大肠埃希菌产ESBLs菌株达81.8%;革兰阳性菌以凝固酶阴性葡萄球菌为主,占50.0%,其次是肠球菌属,占25.0%;另检出真菌10株占9.6%,以假丝酵母菌属为主。结论严格控制使用广谱抗菌药物、预防使用抗真菌药物,是预防超低出生体重儿医院感染的关键。OBJECTIVE To review the incidence of nosocomial infections, distribution of pathogens ,and the drug susceptibility so as to provide basis for the effective control of nosocomial infections in the extremely low birth weight infants. METHODS From Jul 2006 to Jun 2011, totally 70 cases of extremely low birth weight infants with nosocomial infections in neonatal intensive care unit were retrospectively analyzed. RESULTS The pneumonia and sepsis were the main manifestations of hospital infections in the extremely low birth weight infants. Totally 104 strains of pathogens were isolated, consisting of 66 strains of gram-negative baciUi（63.5 %）, 28 strains of gram- positive cocci （26. 9%）, and 10 strains of fungi （9. 6%）. Klebsiella pneumonia was the most common gram-negative bacilli, the ESBLs-producing strains accounted for 100.0 %, the ESBLs-producing Escherichia coli accounted for 81.8 % ; the most common gram-positive bacteria were coagulase-negative Staphylococci（50.0 %）, followed by Enterococci （25. 0%） ; the most common fungi were Candida. CONCLUSION It is of the key to prevent the nosocomial infections in the extremely low birth weight infants to strictly use broad spectrum antibiotics and prevent antifungal use.

关 键 词：超低出生体重儿 医院感染 耐药性 

分 类 号：R722.13[医药卫生—儿科]