不同厂家牛黄解毒片抑菌作用的比较  

Antibacterial effect of nihuangjiedu tablets from different manufacturers: a comparative study

作　　者：白林[1] 黄晓舞[1] 高翠萍[1] 

机构地区：[1]解放军总医院药检室,北京100853

出　　处：《中华医院感染学杂志》2013年第2期444-445,共2页Chinese Journal of Nosocomiology

摘　　要：目的根据回收率试验比较不同厂家生产的牛黄解毒片抑菌作用的强弱,确定适宜的微生物限度检查方法。方法采用微生物限度检查方法,对牛黄解毒片进行方法学验证。结果不同厂家生产的牛黄解毒片抑菌作用不同,抑菌作用最强的采用离心加薄膜过滤法,回收率>70.0%。结论通过对7个厂家生产的牛黄解毒片抑菌作用强弱进行比较,为该品种的微生物限度方法的建立提供参考和依据。OBJECTIVE To establish the method to determine the microbial limit viable count tests for nihuangjiedu tablets from different manufacturers according to the recovery test to compare the strength of inhibition of nihuangjiedu tablets. METHODS By means of the microbial limit test, the validation of the Niuhuangjiedu tablets was determined. RESULTS Nihuangjiedu tablets from different manufactures had different antibacterial effects, the centrifugal sedimentation plus membrane filtration method had the most powerful antibacterial effect with the recovery rate more than 70.0%. CONCLUSION The test of the antibacterial effect of the Niuhuangjiedu tablets from seven manufactures has provided reference for establishing the microbial limit test method

关 键 词：牛黄解毒片 微生物限度检查 离心加薄膜过滤法 

分 类 号：R978.1[医药卫生—药品]