检测肝硬化合并幽门螺杆菌感染患者血氨水平的临床意义  

Detection of Helicobacter Pylori Infection in Patients with Liver Cirrhosis Combined Blood Ammonia Levels of Clinical Significance

作　　者：蔡旭[1] 苑翼容[1] 

机构地区：[1]泸州医学院附属医院检验科,四川泸州646000

出　　处：《医学信息》2013年第1期204-205,共2页Journal of Medical Information

摘　　要：目的探讨Hp感染对乙肝后肝硬化患者血氨的影响及在肝性脑病发生过程中的作用及检测血氨的临床意义．方法选择128例乙型肝炎后肝硬化患者，采用14-C呼气试验，快速尿素酶检测以及血清Hp—IgG抗体（ELISA法）检测Hp感染情况，同时测定其空腹血氨水平．并采用标准Hp根除方案治疗。结果①肝硬化Hp阳性患者的血氨水4-较Hp阴性患者明显升高；②Hp感染对肝硬化血氨的影响与其肝功能分级密切相关。（固Hp阳性的肝性脑病患者其血氨浓度明显高于Hp阴性的肝性脑病患者；（D对肝硬化患者Hp感染阳性者Hp根除治疗后可使血氨显著降低。结论Hp感染与乙肝后肝硬化的血氨浓度升高密切相关，并易发肝性脑病；对Hp感染肝硬化患者血氨浓度的检测．并及时根除Hn有利干予币防和浩疗肝性脑病．具有重要的临床意义．Objective To study the relationship between ammonia concentration levels and Helicobaeter pylnri （Hp） infection in cirrhotic patients. Methods 128 cin-hotic patients were divided into Hp positive group and Hp negative group, who were given one week therapy of eradicating Hp, and then compared the level of blood ammonia before therapy and after therapy 4 weeks. Results The blood ammonia concentration in Hp positive group was significantly higher than that in the Hp negative group （P〈0.05）, and it decreased markedly after Hp eradicating therapy; In Hp positive group, the blood ammonia concentration increased with increasing Child- Pugh grades from A to C （ P 〈0.05）; The blood ammonia concentration in Hp positive patients with hepatic encephalopathy was significantly higher than that in the Hp negative patients with hepatic encephalopathy （P〈0.05）. Conclusion There is close correlation between Hp infection and the serum ammonia concentration in cirrhotic patients. Hp eradication can reduce blood ammonia level, which may be helpful in the prevention and treatment of cirrhotic patients with hepatic eneephalopathy.

关 键 词：肝硬化 幽门螺杆菌 血氨 肝性脑病 

分 类 号：R446.5[医药卫生—诊断学]