不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应研究进展  

Progress in Asymmetric Organocatalyzed Michael Addition/Hemi-aminoacetalization/Acylimminium-Cyclization Cascade Reactions

作　　者：陈杰[1] 刘钦[1] 戴小鸯[1] 聂凛凛[1] 房辉辉[1] 吴小余[1] 

机构地区：[1]上海大学化学系,上海200444

出　　处：《有机化学》2013年第1期1-17,共17页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20802043;210072125)资助项目~~

摘　　要：随着近十多年来不对称有机小分子催化的发展,以这类催化为基础的串联反应也取得了很大的进展.综述了近几年来不对称有机催化Michael加成/半缩醛胺化/酰亚胺正离子环化串联反应构建手性氮杂多环结构的研究进展,介绍了国内外多个课题组对这一类反应的研究结果以及该类反应在生物碱合成中的应用.During the last decades along with the development of asymmetric organocatalysis, tremendous achievements have been made in asymmetric organocatalytic domino or cascade reactions. Herein, the examples of domino or cascade reactions based on asymmetric organocatalyzed Michael addition are described. More specifically, this review aims to cover and discuss the hemi-aminoacetalyzation/acylimminium-cyclization initiated by Michael addition, and the application of this type of reac- tions in the synthesis of alkaloids.

关 键 词：有机催化 串联反应 氮杂多环 生物碱 

分 类 号：O643.3[理学—物理化学]