乌药烷型倍半萜及其二聚体的全合成研究进展  

Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers

作　　者：乐贵洲[1,2] 杨立[1] 袁长春[1] 杜彪[1] 刘波[1,3] 

机构地区：[1]四川大学化学学院绿色化学与技术教育部重点实验室,成都610064 [2]四川农业大学生命科学与理学院,雅安625014 [3]中国科学院上海有机化学研究所中国科学院天然产物合成化学重点实验室,上海200032

出　　处：《有机化学》2013年第1期90-100,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20872098,21021001,21172154);国家重点基础研究发展规划(973计划,No.2010CB833200)~~

摘　　要：乌药烷型倍半萜及其二聚体是一大类具有cis,trans-3/5/6三并环特殊骨架的天然产物,主要是从金粟兰科植物中分离得到.大多数乌药烷型倍半萜及其二聚体具有显著的生物活性,如抗真菌、对B细胞有毒性介导的免疫抑制及对延迟整流钾电流有选择性的抑制作用等.综述了国内外有机化学家对该类天然产物的全合成研究进展.Lindenane-type sesquteripenoids and their dimers, mainly isolated from chloranthaceae, are a big family of natural products, which possess novel polycyclic framework embedded with a sterically congested cyclopentane （ring B）, an unusual trans-5/6 ring junction, and an angular methyl group. Moreover, many of them exhibited impressing bioactivities, for example remarkable antifungal activity, toxicity-mediated immunosuppression against B cells, and selective inhibition on the delayed rectifier K＋current. In this review, the progress in the total syntheses of lindenane-type sesquiterpenoids and their dimmers is summarized.

关 键 词：乌药烷 倍半萜 二聚体 全合成 

分 类 号：O629.61[理学—有机化学]