小蓟流动性饮片的制备及其与传统饮片的比较  

Preparation of Flow Yinpian of Cirsium setosum and Comparison with Traditional Pieces

作　　者：王苗苗[1] 迟宗良[1] 丛晓东[1] 焦坤[1] 张云[1] 蔡宝昌[1] 

机构地区：[1]浙江中医药大学中药炮制技术研究中心,杭州311401

出　　处：《中国实验方剂学杂志》2013年第2期20-23,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：浙江省中医药重点项目研究计划(2008ZA002);浙江省教育厅省级药学类工程实践基地建设项目(浙教函[2008]24号)

摘　　要：目的:优选小蓟新型流动性饮片的制备工艺,并与传统小蓟饮片进行比较。方法:以蒙花苷质量分数为指标,选取粉碎度、加水量、滚丸转速为考察因素,采用正交试验优选流动性饮片的制备工艺;利用TLC,HPLC,红外等对小蓟传统饮片和流动性饮片进行比较。结果:优选的制备工艺为粉碎度80目,加1.8倍量水,滚圆转速300 r.min-1,制备的流动性饮片平均粒径(1.94±0.20)mm,圆整度9.09～27.7,堆密度0.394 3 g.cm-3,真密度0.655 7 g.cm-3,平均硬度6.2 N,平均脆碎度0.30%。二者TLC图谱相同,传统饮片和流动性饮片中蒙花苷分别为0.64%,0.72%。二者煎出曲线较为接近,小蓟流动性饮片和传统饮片煎液的红外图谱基本一致。结论:小蓟新型流动性饮片和传统型饮片在药学上具有对等性,可替代使用。Objective： To optimize preparation technology for Flow Yinpian of Cirsium setosum, and compare with traditional Yinpian of C. setosum. Method： With the mass fraction of linarin as index, orthogonal method was used to investigate influence of grinding degree, the amount of water, roll pill speed on preparation technology; TLC, HPLC, SD-IR were used to compare traditional Yinpian with Flow Yinpian of C. setosum. Result： Optimized preparation technology was as following： grinding degree 80 mesh, the amount of water 1.8 times, roll pill speed 300 r ·min-1 mean particle size of prepared Flow Yinpian of （1.94 ± 0.20） mm roundness of 9.09-27.7, bulk density 0. 394 3 g·cm-3 true density 0. 6557 g · cm-3 mean hardness 6.2 N mean friability 0. 30%. Their TLC were similar, the content of linarin was 0. 64% in traditional Yinpian, while it was 0. 72% in Flow Yinpian. Decoction curve of them was close, IR spectroscopy of their decoction was nearly the same. Conclusion： Traditional Yinpian and Flow Yinpian of C. setosum was reciprocity in pharmacy, they could substitute for each other.

关 键 词：小蓟 流动性饮片 对比研究 红外二阶导数光谱法 复杂体系评估 

分 类 号：R283.6[医药卫生—中药学]