木香中去氢木香内酯和木香烃内酯提取工艺优选  

Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from Aucklandia lappa

作　　者：周广涛[1] 高鹏[1] 戴兵[1] 代龙[1] 

机构地区：[1]山东中医药大学,济南250355

出　　处：《中国实验方剂学杂志》2013年第2期40-42,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:优选木香中去氢木香内酯和木香烃内酯的提取工艺。方法:以木香烃内酯和去氢木香内酯提取率为指标,采用单因素试验考察提取方法;以木香烃内酯和去氢木香内酯提取率为指标,选取乙醇体积分数、料液比、提取时间及提取次数为考察因素,通过正交试验优选2种内酯的提取工艺。结果:最佳提取工艺为采用乙醇温浸法,加6倍量90%乙醇于40℃温浸提取2次,每次2 h。木香烃内酯提取率92.3%,去氢木香内酯提取率94.1%,得膏率12.7%。结论:优选的提取工艺稳定可行,木香中2种内酯的提取率高,适用于工业大生产。Objective： To optimize extracting technology of costunolide and dehydrocostus lactone from Aucklandia lappa. Method： With extraction rate of costunolide and dehydrocostus as indexes, extraction method was screened by single factor test; With extraction rate of costunolide and dehydrocostus as indexes, orthogonal test was used to evaluate effect of 4 factors on extracting technology, including solid-liquid ratio, the concentration of ethanol, extraction time and times. Result： The best extraction method was ethanol warm immersion method,optimum extracting technology was as follows： warm immersion extracted 2 times with 6 times the amount of 90% ethanol, respectively, extraction time of 2 hours. Extraction rate of costunolide and dehydrocostus lactone were 92.3, 94. 1%, respectively, and extract yield wasl2.7%. Conclusion： This optimized extracting technology was stable and feasible with high extraction rate of two kinds lactone from A. lappa, it was suitable for industrial production.

关 键 词：木香 木香烃内酯 去氢木香内酯 提取工艺 

分 类 号：R283.6[医药卫生—中药学]