止泻合剂的质量标准研究  

Studies on Quality Specification of Zhixieheji

作　　者：王迅[1] 周琴妹[1] 吴旭彤[1] 刘顺[1] 

机构地区：[1]江苏省中医院药学部,南京210029

出　　处：《中国实验方剂学杂志》2013年第2期126-129,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:建立止泻合剂的质量标准。方法:采用TLC对制剂中的主要药材进行定性鉴别,用HPLC测定芍药苷的含量。结果:用TCL鉴别止泻合剂中的秦皮、白芍、苍术、地锦草、木香等有效成分,方法简便易行、专属性强、重复性好,检出斑点清晰。芍药苷进样量在0.509～16.31 mg.L-1,线性关系良好,平均加样回收率为96.79%,RSD 1.7%(n=6)。结论:所建立的TLC和HPLC方法简便,专属性强,重复性好,可用于止泻合剂的质量控制。Objective： To establish the quality specification of Zhixieheji. Method： TCL method to identify the active ingredient of Zhixieheji of Cortex Fraxini, Paeoniae Radix, Atractylodes Lancea, Euphorbiae Humifusae, Radix Aucklandiae. The method is simple, specific, and reproducible; detection spots were clear. Of paeoniflorin in the injection volume 0. 509-16.31 mg ·L-1, and linear range of the relationship is good. The average recovery was 96.79% , RSD was 1.7% （n =6）. Conclusion： The method is simple, efficient, sensitive and can be applied to quality control of Zhixieheji.

关 键 词：止泻合剂 芍药苷 TLC法 HPLC 

分 类 号：R284.1[医药卫生—中药学]