龙利叶根急性毒性和抗炎作用的研究  

Studies on Acute Toxicity and Anti-inflammatory Effect of Root of Sauropus rostratus

作　　者：丘琴[1] 甄汉深[1] 王莹[2] 姜建国[3] 杨永榆[3] 

机构地区：[1]广西中医药大学,南宁530001 [2]柳州市中医院,广西柳州545001 [3]北海市第二人民医院,广西北海536000

出　　处：《中国实验方剂学杂志》2013年第2期286-288,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西北海市科研项目(北科项00803001)

摘　　要：目的:研究龙利叶根水煎液的急性毒性和抗炎作用。方法:采用改良寇氏法对急性毒性进行研究,采用二甲苯所致小鼠耳廓肿胀、醋酸所致小鼠腹腔毛细血管通透性等急性炎症模型,小鼠棉球肉芽肿的慢性炎症模型,评价龙利叶根的抗炎效果。结果:龙利叶根水煎液的LD50为152.24 g.kg-1,其高、中、低剂量(20,10,5 g.kg-1)能降低二甲苯所致小鼠耳肿胀程度,降低醋酸所致小鼠腹腔毛细血管通透性和降低小鼠棉球肉芽肿的湿重(P<0.05或P<0.01)。结论:龙利叶根水煎液毒性较小,具有较好的抗炎作用,为龙利叶的开发和利用提供了科学依据。Objective： To study acute toxicity, anti-inflammatory effect of water extract of the root of Sauropus rostratus. Method： Determined the LD50 of the water extract by modified Karber＇s method, Dimethylbenzene-induced auricle edema in mice, capillary permeability induced by acetic acid and cotton ball- induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of root of S. rostratus. Result： The LDs0 of water extract of root of S. rostratus, was 152.24 g ~ kg-1 The auricle edema induced by dimethylbenzene in mice, capillary permeability induced by acetic acid and catton ball-induced granuloma in mice were inhibited significantly by water extract of root of S. rostratus. （P 〈0. 05 or P 〈 0.01 ）. Conclusion： The water extract of root of S. rostratus. Had low toxicity and had anti-inflammatory effect. The researches provided a scientific basis for the developping and utilizing of S. rostratus.

关 键 词：龙利叶根 急性毒性 抗炎作用 

分 类 号：R285.5[医药卫生—中药学]