聚乙二醇负载的二茂铁噁唑啉配体的合成及其应用(英文)  

Synthesis of MeO-PEG-Supported Ferrocenyloxazoline Ligands and Their Application in Asymmetric Catalysis

作　　者：刘洪强[1,2] 时磊[1] 陈庆安[1] 王磊[2] 周永贵[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116023 [2]淮北师范大学,淮北市235000

出　　处：《化学学报》2013年第1期40-43,共4页Acta Chimica Sinica

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21202162&21125208);the National Basic Research Program of China(No.2010CB833300)~~

摘　　要：报道了聚乙二醇(MeO-PEG)负载的二茂铁噁唑啉衍生的手性N,P和N,S配体的合成.所得负载N,P配体可以成功应用于银催化的[3+2]环加成反应,最高取得了97%的对映选择性.另外聚乙二醇负载二茂铁N,S配体可以成功应用于钯催化的烯丙基取代反应,取得了90%的ee值.值得注意是,聚乙二醇负载形成的催化剂循环使用4次后其催化活性和选择性仍可基本保持.A simple synthesis of ferrocenyloxazoline derived chiral N,P ligands and N,S ligands immobilized on a MeO- PEG-support is described. The metal complexes of chiral ligands have been successfully applied to 1,3-dipolar cycloaddition reaction of azomethine ylides and asymmetric allylic substitution reaction, providing the products with up to 97% ee and 90% ee, respectively. The MeO-PEG-supported metal complex catalysts can be recycled easily and reused.

关 键 词：聚乙二醇 二茂铁噁唑啉 不对称催化 

分 类 号：O634[理学—高分子化学]