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作 者:李洵[1] 刘秋琼[1] 陈文颖[1] 黄李琳 林秋晓[1] 谭淑敏[1]
机构地区:[1]广东省人民医院药学部/广东省医学科学院,广州510080 [2]中山市食品药品监督管理局,广东中山528400
出 处:《中国药房》2013年第4期367-369,共3页China Pharmacy
摘 要:目的:了解钙拮抗药致心脏不良反应(ADR)的发生特点及规律,以减少ADR的重复发生。方法:对广东省2002年1月-2012年6月上报的63例钙拮抗药致心脏ADR进行统计、分析。结果:心脏ADR的发生与性别关系不大,与年龄关系密切,以41岁以上的中、老年患者居多;ADR发生时间多集中在24h内;二氢吡啶类钙拮抗药引起的ADR比例最高(60例,95.24%);心脏ADR临床表现以心悸、心动过速、心律失常等为主,其中心悸构成比例最高(76.19%);心脏ADR报告药物剂型以普通片构成比例最高(58.73%),缓、控释制剂导致的ADR明显减少。结论:应加强高血压患者应用钙拮抗药的ADR监测工作,及时预防、上报ADR,以降低ADR的发生率。OBJECTIVE:To probe into the occurrence of calcium antagonists induced cardiac adverse reactions(ADR),and to explore the regularity of it in order to provide guidance for clinical rational drug use and ensure safe and effective drug use.METHODS:A total of 63 cases of calcium antagonists drug induced cardiac ADR reported by Guangdong province between Jan.2002 and Jun.2012 were analyzed statistically.RESULTS:The occurrence of cardiac ADR was not significantly associated with gender but closely related with age.ADR was mostly found in elderly patients aged 41 years old or above;the time of ADR occurred mostly within 1 day;dihydropyridine calcium antagonist caused cardiac ADR took up the highest proportion(60 cases,95.24%);main clinical manifestations were heart palpitations,tachycardia,arrhythmias and so on,and palpitation occupied the highest percentage(76.19%);high proportion of cardiac ADR were caused by conventional tablets(58.73%),and the number of cardiac ADR induced by controlled or sustained-release formulations was reduced significantly.CONCLUSION:ADR monitoring,timely prevention,reporting and updating of ADR should be more emphasized in hypertensive patients receiving calcium antagonist to reduce the incidence of ADR and further enhance the effect of drug treatment.
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