ACI患者血清Hcy、hs-CRP和TGF-β1检测的临床意义  

Clinical Significance of Measurement on the Changes of Serum Hcy, hs-CRP and TGF-β1 Levels in Patients with Acute Cerebral Infarction(ACI)

作　　者：杜莉[1] 王延稳[1] 段大磊[1] 

机构地区：[1]江苏省新沂市铁路医院,221400

出　　处：《放射免疫学杂志》2013年第1期20-22,共3页Journal of Radioimmanology

摘　　要：目的:探讨了急性脑梗死(ACI)患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化及临床意义。方法:应用免疫化学法、免疫比浊法和放射免疫分析对32例ACI患者进行了治疗前后血清Hcy、hs-CRP和TGF-β1检测,并与35名正常健康人作比较。结果:ACI患者在治疗前血清Hcy、hs-CRP和TGF-β1水平均非常显著地高于正常人组(P<0.01),经治疗1个月后则与正常人组比较无显著性差异(P>0.05)。血清Hcy水平与hs-CRP、TGF-β1水平呈正相关(r=0.6146、0.5784,P<0.01)。结论:检测ACI患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化对了解病情、观察预后均具有重要的临床价值。Objective To explore the clinical significance of measurement on the changes of serum Hcy,hs-CRP and TGF-β1 levels after treatment in patients with ACI. Methods Serum Hcy （with immunochemistry）, serum hs-CRP （with immunoturbidime- try）, serum TGF-β1 （with RIA） levels were determined in 32 patients with ACI and 35 normal healthy controls. Results Before treatment, serum Hey, hs-CRPand TGF-β1 levels in the patients were significantly higher than those in controls （P 〈 0. 01 ）. After treat- ment for 1 month, serum Hey, hs-CRP and TGF--βI levels were no significant difference （P 〉 0.05 ）. Serum Hey level showed positive- ly correlated with hs-CRP,TGF-β1 levels （r = 0. 6146 ,0. 5784 , P 〈 0.01 ）. Conclusion Detection the changes of serum Hey, hs-CRP and TGF-β1 levels after treatment in patient with ACI might be helpful to monitor efficacy of therapy and prognosis. Therefore, possess important clinical value.

关 键 词：急性脑梗死 同型半胱氨酸 超敏 C-反应蛋白 转化生长因子-Β1 

分 类 号：R541.4[医药卫生—心血管疾病]