血浆ANF与^(99m)Tc-DTPA肾动态显像的联合监测在糖尿病肾病中的意义  

Plasma ANF and ^(99m)Tc-DTPA Renal Dynamic Imaging Combined Monitoring in the Significance of Diabetic Nephropathy

作　　者：余飞[1] 吕明丽[1] 蔡海东[1] 李丹[1] 袁雪宇[1] 吕中伟[1] 

机构地区：[1]同济大学附属第十人民医院核医学科,200072

出　　处：《放射免疫学杂志》2013年第1期22-24,共3页Journal of Radioimmanology

摘　　要：目的:通过血浆ANF与99mTc-DTPA肾动态显像的联合测定,对糖尿病肾病(DN)进行准确的诊断和临床分期。方法:选取我院70例2型糖尿病(DM2)患者(排除心、脑、血管疾病、泌尿系感染)及正常健康者40名作为正常对照组。70例DM2患者分为2组,A组35例为早期DN组,糖尿病病程为(5～10)年,血BUN、Cr没有明显变化,B组35例为中晚期DN组,糖尿病病程>10年,血BUN、Cr有不同程度升高。分别测定血浆ANF和GFR。结果:A组及B组ANF含量均高于正常对照组(P<0.01),且B组明显高于A组(P<0.01);A组GFR测定高于正常对照组(P<0.05),B组GFR低于正常对照组(P<0.01)。结论:实验表明,DN早期GFR值升高,ANF值升高,中晚期DN患者GFR值降低,但ANF值升高更为明显。Objective The study examined GFR by the ^99mTc-DTPA renal dynamic imaging and plasma ANF to get the diabetic nephropathy＇s definite diagnosis and the clinical stages. Methods selected 70 patients with type 2 diabetes in our hospital （barring the heart, brain, vascular diseases and urinary tract infection） and 40 normal healthy persons served as control group. 70 cases of type 2 diabetes patients were divided into two groups, Group A with 35 cases of early diabetic nephropathy, duration of diabetes for 5-10 years, blood BUN, Cr changed unsignificantly, Group B with 35 cases of middle-late diabetic nephropathy, duration of diabetes 〉 10 years, blood BUN, Cr showed different levels rising. Results ANF examination, both of A group and B were higher than those in control group, the difference is highly significant （P 〈 0. 05） and B group obviously higher than the group A, the difference is highly significant （P 〈 0.05 ） ; GFR examination, the group A higher than that of control group, the difference is significant （P 〈 0.05 ）, group B manifested below the control group, the difference showed markedly significant （P 〈 0.05） Conclusion The experiment indicated, in early stage of diabetic nephropathy GFR is increasing and ANF also increasing, diabetic nephropathy in middle-late stage GFR is reducing but ANF is increasing more obviously.

关 键 词：糖尿病肾病 血浆心钠素 放射免疫分析 肾小球滤过率 

分 类 号：R692.04[医药卫生—泌尿科学]