原发性高血压患者血浆ET-1水平与脂质过氧化关系的探讨  

A Study on the Relationship Between the Plasma ET-1 Level and Lipid Peroxidation in Patients with Primary Hypetension

作　　者：左新春 

机构地区：[1]江苏省沭阳县仁慈医院心内科,223600

出　　处：《放射免疫学杂志》2013年第1期25-27,共3页Journal of Radioimmanology

摘　　要：目的:探讨原发性高血压患者血浆ET-1水平与脂质过氧化的关系。方法:分别应用放免法和生化法对33例高血压患者进行血浆ET-1、丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量测定,并与35名正常健康人作比较。结果:原发性高血压患者血浆ET-1、MDA水平非常显著地高于正常人组(P<0.01),而血清SOD、GSH-PX水平非常显著地低于正常人组(P<0.01)。相关分析显示,血清SOD、GSH-PX水平与MDA水平呈显著负相关(r=-0.4218、-0.4011,P<0.01)。结论:原发性高血压患者血清SOD、GSH-PX水平的降低与活性代谢紊乱密切相关。Objective To assess the relationship between the plasma ET-1 level and lipid peroxidation in patients with primary hypertension. Methods Plasma ET-1 （with ELISA）, serum MDA, SOD and GSH-PX （with biochemistry） levels were measured in 33 patients with primary hypertension and 35 normal controls. Results Plasma ET-1, MDA levels were significantly higher in patients with primary hypertension than those in controls（ P 〈 0.01 ）, but serum SOD, GSH-PX levels were obviously lower（ P 〈 0.01 ）. Serum SOD, GSH-PX levels were negatively correlated with MDA level （ r = -0.4218,-0.4011,P 〈 0.01 ）. Conclusion Decreases of serum SOD, GSH-PX levels were closely related with the disorder of active metabolism in patients with primary hypertension.

关 键 词：原发性高血压 内皮素 丙二醛 超氧化物岐化酶 谷胱甘肽过氧化物酶 

分 类 号：R544.1[医药卫生—心血管疾病]