国产BRDⅡ株风疹减毒活疫苗加强免疫后6～7年血清学效果观察  

The Serological Effect on Domestic BRD II Strain Rubella Attenuated Live Vaccine after 6-7 Years Second Dose Vaccination

作　　者：许青[1] 徐爱强[1] 宋立志[1] 王常银[1] 张丽[1] 熊萍[1] 李炜修[1] 

机构地区：[1]山东省疾病预防控制中心,济南250014

出　　处：《中国疫苗和免疫》2012年第6期504-507,共4页Chinese Journal of Vaccines and Immunization

基　　金：山东省医药卫生科学研究项目(编号2009HD014)

摘　　要：目的观察儿童国产BRDⅡ株风疹减毒活疫苗(Rubella Attenuated Live Vaccine,RV)再次免疫(再免)后的血清学免疫效果,探讨风疹免疫策略。方法 2008年在山东省蓬莱、海阳县,追踪观察6～18月龄初次免疫(初免)国产BRDⅡ株RV免疫成功、且在7岁时再免1剂的未患过风疹的儿童,采用酶联免疫吸附试验检测风疹免疫球蛋白(Immunoglobulin,Ig)G抗体。结果 232名6～18月龄RV初免成功儿童,7岁时再免6～7年后,风疹IgG抗体阳性率平均为97.41%,抗体几何平均浓度(Geometric Mean Concentration,GMC)为44.27国际单位/毫升(IU/ml),不同初免月龄、不同初免抗体水平间风疹抗体阳性率和GMC差异均无统计学意义,初免2年后抗体转阴儿童,再免6～7年后抗体均阳性。结论儿童7岁时再免国产RV后6～7年,风疹抗体仍保持在较高水平,对预防学龄儿童风疹爆发、保护育龄期妇女有重要作用。Objective To study the serological effect after vaccinated the second dose domestic BRD II strain rubella attenuated live vaccine among children, and to formulate rubella immune strategy. Methods The children were selected for the observation of the serological effect who were immunized successfully at age 6-18 months by first dose domestic BRD 1[ strain rubella attenuated live vaccine and inoculating second dose at 7 years old without rubella infection in Penglai and Haiyang counties in Shandong in 2008, The rubella-specific Immunoglobulin （Ig）G antibodies was tested by enzyme linked immunosorbent assay （ELISA）. Results 232 children inoculating second dose rubella attenuated live vaccine for 6-7 years were observed. The positive rate of rubella IgG was 97.41% and the geometric mean consistence （GMC） was 44.27 IU/ml. There was no significant difference on positive rate and GMC among children who are at different months got the first dose and among children who are at different antibody level of first dose. Rubella antibody turned negative after first dose for two years were positive after second dose for 6-7 years. Conclusions The rubella IgG was high level after inoculating second dose of rubella attenuated live vaccine for 6-7 years. It is important to prevent rubella outbreak for school children and productive weman.

关 键 词：风疹减毒活疫苗 再次免疫 血清学效果 

分 类 号：R186[医药卫生—流行病学] R511.2[医药卫生—公共卫生与预防医学]