甲型H_1N_1流行性感冒疫苗保护效果研究  

Investigation on the Epidemiology Effect of Influenza A(H_1N_1)Vaccine

作　　者：张国民[1] 王华庆[1] 夏伟[1] 李慧[2] 张晋琳[3] 闫滨[4] 马玉忠[5] 祁旺[1] 姜柯羽[1] 殷大鹏[1] 肖奇友 刘燕敏[1] 

机构地区：[1]中国疾病预防控制中心免疫规划中心,北京100050 [2]甘肃省疾病预防控制中心,兰州730000 [3]江苏省疾病预防控制中心,南京210009 [4]黑龙江省疾病预防控制中心,哈尔滨150030 [5]邯郸市疾病预防控制中心,河北邯郸056000 [6]中国生物技术股份有限公司,北京100029

出　　处：《中国疫苗和免疫》2012年第6期515-517,共3页Chinese Journal of Vaccines and Immunization

基　　金：国家高技术研究发展计划(863计划)项目<甲型H1N1流感疫苗规模化生产新工艺新方法的研发>子课题<甲型H1N1流感病毒裂解疫苗上市后效果和安全性评价>(编号:2010AA022910)

摘　　要：目的评价甲型H1N1流行性感冒(流感)(甲流)疫苗上市后大规模应用的保护效果。方法 采用队列研究的方法 ,选择7个省的10个县作为调查地区,通过整群抽样选择部分学校的师生,按照接种疫苗和未接种疫苗分组,对疫苗保护效果进行评价。结果接种甲流疫苗组和未接种组的流感样病例(InfluenzaLikeIllness,ILI)罹患率分别为0.51%和1.29%,差异有统计学意义(2=122.1,P<0.001),保护率为60.47%,效果指数为2.5;接种甲流疫苗组的ILI罹患率为0.45%,与未接种组比较差异有统计学意义(2=95.980,P<0.001),保护率、效果指数分别为65.11%、2.9;接种季节性流感疫苗组的ILI罹患率为0.62%,与未接种组比较差异有统计学意义(2=42.622,P<0.001),保护率为51.94%,效果指数2.1;未接种甲流疫苗组甲流病例罹患率(0.07%),高于接种组罹患率(0.03%),差异无统计学意义(2=3.367,P=0.067),接种甲流疫苗的甲流病例保护率为57.14%,效果指数为2.3。结论甲流疫苗对包括甲流在内的ILI有较好的保护效果。Objective To assess the epidemiology effect on the mass vaccination of influenzaA（HlNl） vaccine. Method The cohort study design were used. 10 counties from 7 provinces were selected. The school students were divided into vaccinations and un-vaccinations group, and to evaluate the effect of influenzaA （HIN1） vaccine. Result The incidence of influenza like illness （ILI） of vaccinations [include the influenza A （H1NI） vaccine and the seasonal flu vaccinel was 0.50%, the incidence of un-vaccinations was 1.30%, the difference between groups was significant, the protective rate was 61.5 %, and the protection index was 2.6; the attack rate of influenza like illness （ILI） of influenza A （H1NI） vaccine vaccinations was 0.45 %, compare to the un-vaccinations, the difference was also significant, the protective rate and the protection index was 65.11% and 2.9 ; the attack rate of influenza like illness （ILl） of seasonal flu vaccine vaccinations was 0.62 %, compare to the un-vaccinations, the difference was significant, the protective rate was 52.31%, the protection index was 2.3 ; there were no significant difference on the attack rate of influenza A case between vaccinations and un- vaccinations, the protective rate was 57.14~,the protection index was 2.3. Conclusion The sInfluenza A （H1N1） vaccine has good epidemiological protective effects on influenza-like illness including influenza A （H1Ni）.

关 键 词：甲型H1N1流行性感冒疫苗 保护效果 流行性感冒样病例 

分 类 号：R186[医药卫生—流行病学] R511.7[医药卫生—公共卫生与预防医学]