右美托咪定用于气管异物患儿气管拔管的镇静效果  

Sedative effect of dexmedetomidine on children undergoing removal of tracheal foreign body during tracheal extubation period

作　　者：雷晓鸣[1] 薛荣亮[1] 钞海莲[1] 吕建瑞[1] 吴刚[1] 党莎杰[1] 邓蕊[1] 靳刚利[1] 

机构地区：[1]西安交通大学医学院第二附属医院麻醉科,710004

出　　处：《临床麻醉学杂志》2012年第12期1190-1192,共3页Journal of Clinical Anesthesiology

基　　金：国家临床重点专科建设项目资助(卫办医政函[2012]650号)

摘　　要：目的观察术前给予右美托咪定对气管异物取出术患儿气管拔管的镇静效果。方法气管异物取出术患儿60例,随机均分为两组,分别在全麻诱导前10min内静脉输注右美托咪定0.5μg/kg(D组)或生理盐水(C组)。术中丙泊酚2mg·kg-1·h-1、瑞芬太尼0.1μg·kg-1·h-1维持麻醉。记录拔管前1min、拔管时、拔管后1、5min时的HR、MAP、RR、Ramsay镇静评分的变化,以及拔管期间呛咳和躁动情况。结果 D组HR、RR、MAP、呛咳评分和躁动评分低于C组(P<0.05),Ramsay镇静评分高于C组(P<0.05)。结论术前给予右美托咪定可为气管异物患儿苏醒期提供较好的镇静,减少拔管期间躁动和呛咳。Objective To observe the sedative effect of dexmedetomidine on children undergoing removal of tracheal foreign body during tracheal extubation period. Methods Sixty children undergoing removal of tracheal foreign body were equally randomized into two groups receiving intravenous infusion of dexmedetomidine 0. 5 μg/kg （group D） and normal saline （group C）, respectively, within 10 min before the induction of anesthesia. HR, MAP, RR, SpO2 and Ramsay sedation score at 1 min before extubation, extubation, 1 min and 5 min after extubation were recorded. Coughing and agitation were observed during extubation period. Results Compared with group C, HR, RR, MAP, and coughing and agitation score were lower and the Ramsay sedation score was higher in group D （P〈0.05）. Conclusion Dexmedetomidine premedieation may provide a good sedation effect for children undergoing removal of tracheal foreign body during anesthesia emergence and reduce coughing and agitation during treacheal extubation period.

关 键 词：右美托咪定 气管异物 气管拔管 镇静 

分 类 号：R726.1[医药卫生—儿科]