催化歧化法合成羟基乙酸  

SYNTHESIS OF GLYCOLIC ACID BY DISPROPORTATIONATION REACTION OF GLYOXAL

作　　者：赵林林[1] 刘华庆[1] 潘巧[1] 杨洲[1] 袁华[1] 

机构地区：[1]武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430073

出　　处：《精细石油化工》2013年第1期21-23,共3页Speciality Petrochemicals

基　　金：湖北省自然科学基金(2010CDB11106);武汉市科技攻关计划(201210321106)

摘　　要：研究了对羟基乙酸的合成新工艺进行。以质量浓度为20%的Ca(OH)2为催化剂,在10～30℃催化乙二醛分子内歧化反应得到羟基乙酸钙,反应时间约1h为宜。羟基乙酸钙再用硫酸酸化得到羟基乙酸,产率大于95%。利用硫酸钙沉淀的形成可以方便地去除金属钙离子,反应选择性好,工艺过程简捷。A new synthetic technology of glycolic acid was studied. Calcium glycollate was synthesized by intramolecular disproportionation reaction from glyoxal with Ca（OH）2 as catalyst, while the mass concentration of Ca（OH）2 was 20% or so, the temperature was controlled between 10- 30℃ and re- action time was about 1 h. Glycolic acid was then obtained through acidification with H2SO4 and the yield was above 95 %. tate. The reaction has Meanwhile, Ca2＋ ion was easily removed through the form of CANO4 precipi good selectivity and simple process.

关 键 词：乙二醛 氢氧化钙 歧化反应 羟基乙酸 

分 类 号：TQ225.12[化学工程—有机化工]