HELLP综合征的研究进展  

Research Progress in HELLP Syndrome

作　　者：郝小强[1] 徐友娣[1] 

机构地区：[1]南京医科大学附属南京医院南京市第一医院妇产科,南京210006

出　　处：《医学综述》2013年第1期123-126,共4页Medical Recapitulate

摘　　要：HELLP综合征是妊娠期高血压疾病的严重并发症,常危及母婴生命,是导致孕产妇及围生儿死亡的原因之一。近年来,国内外学者对其发病机制进行了大量研究,有母胎免疫失衡,血小板聚集与消耗,血管内皮功能障碍及先天性固有脂肪酸氧化失调等学说,但其发病机制目前尚未阐明,可能是子痫前期或子痫的严重并发症,也可能是一种独立的疾病。HELLP syndrome is a serious life-threatening complication of hypertensive disorders in preg- nancy, which is one of the main causes of maternal and perinatal mortality. In recent years, domestic and for- cign scholars have done a lot of studies about its pathogenesis, such as immune imbalance, platelet aggregation and consumption, endothelial dysfunction, congenital disorder of oxidation of fatty acid, but its pathogenesis is still not clarified. It may be an independent disease or aserious complication of preeclampsia or eclampsia.

关 键 词：HELLP综合征 人类白细胞抗原G 凝血酶敏感蛋白1 长链L-3-羟酰CoA脱氢酶 瘦素 

分 类 号：R714.25[医药卫生—妇产科学]