人类胚胎发育、精子发生与DNA甲基化关系的研究进展  

Research Progress in Human Embryonic Development,Spermatogenesis and DNA Methylation

作　　者：江莉[1] 覃莉[1] 李慕军[1] 

机构地区：[1]广西医科大学第一附属医院生殖中心,南宁530021

出　　处：《医学综述》2013年第2期197-199,共3页Medical Recapitulate

基　　金：广西高校科研资助项目课题(桂教200103YB023)

摘　　要：表观遗传是指基因的核苷酸序列不发生变化,但基因表达却发生了可遗传的改变。DNA甲基化是表观遗传重要的调控机制,它参与了动物胚胎发育、基因印迹和X染色体失活等过程,在基因表达的调控中具有重要作用。DNA甲基化可引起基因组中相应区域染色质结构变化,使染色质高度螺旋化,凝缩成团,失去转录活性。现对DNA甲基化与人类胚胎发育与精子生成的关系等进行综述。Abstraet：Epigenetics refers to the genetic nucleotide sequence does not change,while gene expression has a heritable change. DNA methylation is an important regulatory mechanism of epigenetics, which is in- volved embryonic development, genomic imprinting and X chromosome inactivation process, playing a signifi- cant role in the regulation of gene expression. DNA methylation can cause changes in chromatin structure ot the corresponding region, and make the chromatin so highly helical that condense into a ball, and then lose transcriptional activity. Here is to make a review on the relationship between DNA methylation and human embryonic development and spermatogenesis.

关 键 词：表观遗传 DNA甲基化 胚胎发育 精子发生 

分 类 号：R715.5[医药卫生—妇产科学]