重度脓毒症时中性粒细胞迁移能力障碍机制的研究进展  

Research Advances in the Mechanisms of Neutrophils Migration Failure during Severe Sepsis

作　　者：孟晨阳[1] 陈红光[2] 孟啸寅[2] 付国俊 

机构地区：[1]河北沧州医学高等专科学校生化教研室,河北沧州061001 [2]天津医科大学研究生院,天津300052 [3]河北省沧州市人民医院皮肤科,河北沧州061001

出　　处：《医学综述》2013年第2期210-213,共4页Medical Recapitulate

摘　　要：脓毒症是由感染引起的全身炎性反应综合征,而一半以上的脓毒症患者会发展为重度脓毒症,其病死率50%以上。中性粒细胞是人体抵御外来微生物入侵的第一道防线,是固有性免疫系统中重要的效应细胞。大量研究发现,中性粒细胞的迁移能力障碍在脓毒症的发生、发展过程中发挥重要作用,具体机制与诱导型一氧化氮合酶诱生的一氧化氮、血红素氧合酶、急性期蛋白和趋化因子等异常变化有关。Sepsis is a systemic inflammatory response syndrome induced by infection. More than half of sepsis will develop into severe sepsis with a mortality of over 50%. Neutrophils are the body＇s first line of de- fense against microbial invasion, important effector cells in the innate immune system. Numerous studies show that neutrophil migration impairment plays a critical role in severe sepsis, which involves with abnormal pro- duction of nitric oxide induced by iNOS, HO ,acute phase proteins, and chemokines.

关 键 词：重度脓毒症 中性粒细胞 迁移能力障碍 机制 

分 类 号：R392[医药卫生—免疫学]