遗传性易栓症相关抗凝因子的研究进展  

Research Progress of the Genetic Thrombophilia Anticoagulant

作　　者：朱锋[1] 戈小虎 

机构地区：[1]石河子大学医学院,新疆石河子832008 [2]新疆自治区人民医院普外科,乌鲁木齐830000

出　　处：《医学综述》2013年第2期213-215,共3页Medical Recapitulate

摘　　要：易栓症可定义为血栓形成的倾向性增高,主要由于凝血系统和抗凝血系统两方面因素造成。易栓症分为遗传性易栓症与获得性易栓症。现就遗传性易栓症的相关抗凝因子进行研究,从分子生物学水平上对抗凝血酶Ⅲ(AT-Ⅲ)、蛋白C(PC)、蛋白S(PS)缺陷的病理机制、疾病的诊断及其相应的实验室检查予以综述。同时,结合近年来相关国内外研究报道提出两个观点:①遗传性AT-Ⅲ、PC、PS缺陷在东西方人群的分布可能存在较大差异;②遗传性易栓症患者中存在联合缺陷。Thrombophilia can be defined as increased tendency to thrombosis, mainly caused by the co- agulation system and anticoagulation system. Thrombophilia is categorized into genetic thrombophilia and ac- quired thmmbophilia. Here is to make a review on genetic thrombophilia factor for anticoagulant-related re- search ,focusing on molecular biology ]evel pathological mechanisms, diagnosis and appropriate laboratory tests of thromhin m （ antithrombin Ⅲ, AT-Ⅲ）, and protein C （ protein C, PC ）, protein S （ protein S, PS） de- fects. Two points put forward according to recent domestic and foreign studes are：（1）Hereditary AT-IU, PC, PS deficiencies distribution in the east and west population may be quite different;（2）patients with hereditary thrombophilia defects have joint defects.

关 键 词：易栓症 蛋白C 蛋白S 抗凝血酶Ⅲ 联合缺陷 

分 类 号：R654.3[医药卫生—外科学]