七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎20例疗效观察  

Clinical effect of sodium aescinate combined with low-dose Prednisolonum in the treatment of 20 cases of subacute thyroiditis

作　　者：李新秋[1] 王玉明[1] 

机构地区：[1]湖北医药学院附属人民医院甲状腺乳腺外科,湖北十堰442000

出　　处：《海南医学》2013年第1期9-11,共3页Hainan Medical Journal

摘　　要：目的观察七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎的疗效。方法将40例亚急性甲状腺炎患者随机分为治疗组和对照组各20例。治疗组应用口服泼尼松5mg／d联合静脉滴注七叶皂苷钠10mg／d治疗，七叶皂苷钠静脉注射10d为一个疗程，间隔一周后继续进行下一个疗程；对照组采用口服泼尼松30mg／d，分3次口服，2周后20mg／d，以后每1-2周减5mg／d至停药。比较两组的症状开始改善的时间、治愈率、不良反应的发生率及停药后复发率。结果两组比较，治疗组症状开始改善的时间短（P〈0．05），治愈率差异无统计学意义（P〉0．05），但对照组复发率高（P〈0．05），药物不良反应发生率高（P〈0．05）。结论静脉注射七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎症状改善快，同时可以降低药物不良反应的发生率和复发率。Objective To observe the curative effect of sodium aescinate combined with low-dose prednisolonum in the treatment of subacute thyroiditis. Methods Forty patients with subacute thyroiditis were randomly divided into two groups： the study group （n=20） and the control group （n=20）. Patients in the study group were treated with 10 mg/d sodium aescinate by intravenous drip combined with oral 5 mg/d prednisolonum. Ten days of sodium aescinate intravenous dripping was designated as a course of treatment, and the next course started with an interval of one week. Patients in the control group were treated with prednisone orally given in decreasing doses： 30 mg/d for the first two weeks, 20 mg/d for 2 weeks, then the dose was tapered by 5 mg/d every one to two weeks. Time of symptoms starting to improve, cure rate, incidence of adverse reactions and recurrence rate after withdraw were compared between the two groups. Results Compared to the control group, the study group had shorter times of symptoms starting to improve （P〈0.05）. There was no statistically significant difference between the two groups in the cure rate （P〉0.05）. The study group had significantly lower incidence of adverse reactions and lower recurrence rate than control group （P〈0.05）. Conclusion Compared with prednisone alone, sodium aescinate combined with low-dose prednisolonum has faster improvement of symptoms, lower incidence of adverse reactions and decreased recurrence rate.

关 键 词：七叶皂苷钠 强的松 亚急性甲状腺炎 

分 类 号：R581.4[医药卫生—内分泌]