血糖控制对2型糖尿病患者认知功能的影响  

Effect of blood glucose control on cognitive function in patients with type 2 diabetes

作　　者：韦晴霏[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院西院内科,广西柳州545006

出　　处：《海南医学》2013年第2期179-181,共3页Hainan Medical Journal

基　　金：广西柳州市科学技术局课题(编号:2010030739)

摘　　要：目的分析血糖控制与2型糖尿病患者认知功能的关系,探讨引起其认知障碍的血糖阈值。方法选取100例2型糖尿病患者作为实验组,给予两年正规降血糖治疗后按照餐后2h血糖水平将实验组分为组别Ⅰ(4.4～8mmol/L)、组别Ⅱ(≤10mmol/L)、组别Ⅲ(10～11.1mmol/L)和组别Ⅳ(>11.1mmol/L),每组25例;于同期选取25例正常人作为对照组。对不同组别研究对象认知功能评分和障碍发生率以及导致认知障碍单因素、多因素进行分析,然后对所得数据进行统计学处理。结果单因素分析显示血糖水平、独居与认知功能下降和障碍存在差异,即P=0.026<0.05和P=0.043<0.05,而多因素分析显示血糖水平和认知功能下降和障碍存在独立正相关性(即P=0.028<0.05),引起糖尿病患者认知功能障碍的血糖阈值为11.1mmol/L。结论血糖水平过高(血糖阈值11.1mmol/L)能明显导致糖尿病者认知功能下降,所以有效控制血糖水平对预防认知功能障碍的发生至关重要。Objective To analyze the relationship between blood glucose control and the cognitive function in patients with type 2 diabetes, to investigate the threshold value of blood glucose that causes cognitive impairment. Methods One hundred patients with type 2 diabetes were selected as research subjects, which were given hypoglyce- mic treatment for two years. The patients were divided into two groups according to 2-hour postprandial blood glu- cose levels, each with 25 cases： groupⅠ （4.4-8 mmol/L）, group Ⅱ （≤ 10 mmol/L）, groups Ⅲ （10-11.1 mmol/L） and group Ⅳ （〉11.1 mmol/L）. Twenty-five healthy individuals were selected as the control group. The cognitive function scores, the incidence of obstacles, and the factors that lead to cognitive impairment were analyzed. Results Univari- ate analysis showed that there was statistically significant difference in blood sugar level, living alone, and cognitive impair- ment, P=0.026〈0.05 and P=0.043〈0.05. Multivariate analysis showed that blood glucose levels was positively correlated with cognitive impairment （P=0.028〈0.05）. The threshold levels of blood glucose that causes cognitive impairment was de- termined to be 11.1 mmol/L. Condusion High blood sugar levels （≥11.1 mmol/L） can obviously lead to cognitive decline and impairment. Effective control of blood sugar levels is crucial to the prevention of cognitive dysfunction.

关 键 词：血糖控制 2型糖尿病 认知功能 

分 类 号：R587.1[医药卫生—内分泌]