冠心病患者血浆游离脂肪酸组分分析  

Determination of free fatty acids in plasma of patients with coronary heart disease by gas chromatography

作　　者：林晖[1] 彭素媚[1] 陈振皋[1] 

机构地区：[1]南京军区福州总医院第一附属医院检验科,福建莆田351100

出　　处：《国际检验医学杂志》2013年第1期23-24,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血浆游离脂肪酸(FFAs)组分及含量与冠状动脉粥样硬化性心脏病(CHD)的关系。方法应用气相色谱技术检测106例CHD患者(CHD组)和106例健康者(对照组)血浆FFAs各组分含量。结果与对照组比较,CHD组血浆游离饱和脂肪酸(软脂酸和硬脂酸)、单不饱和脂肪酸(油酸)、ω6-多不饱和脂肪酸(二十碳三烯酸、亚油酸、花生四烯酸)、ω3-PUFAs(α-亚麻酸和二十二碳六烯酸)含量明显降低(P<0.05),ω6-PUFAs/ω3-PUFAs比值无统计学差异(P>0.05)。结论气相色谱法检测血浆FFAs结果稳定可靠;CHD患者血浆FFAs含量较健康者明显降低,可作为CHD早期监测指标应用于临床。Objective To investigate the relationship between free fatty acids （FFAs） contents and coronary heart disease （CHD）. Methods Gas chromatography method was used to detect plasma levels of variant contents of FFAs in 106 patients with CHD（CHD group） and 106 healthy subjects（control group）. Results Compared with control group,plasma level of free SFA（pal- mitic acid, stearic acid）, MUFAs（oleic acid）, w6-PUFAs（DGLA, linoleic acid and arachidonic acid） and w3-PUFAs （a-linolenic acid and ducosahexenoic acid） in CHD group significantly decreased（P〈0.05）, and the ratio of w6-PUFAs and w3-PUFAs did not change significantly（P〉0.05）. Conclusion Gas chromatography method could detect plasma FFAs with high sensitivity and accuracy. Plasma FFAs could become a monitoring index for CHD in clinical applications.

关 键 词：气相色谱 冠心病 游离脂肪酸 

分 类 号：R541.4[医药卫生—心血管疾病]