AMPK在胆汁酸代谢中的调节作用  

Role of AMPK in regulation of bile acid metabolism

作　　者：何静宇[1] 雷正明[1] 付文广[1] 

机构地区：[1]泸州医学院附属医院肝胆外科,泸州646000

出　　处：《国际外科学杂志》2013年第1期54-57,共4页International Journal of Surgery

摘　　要：腺苷酸活化蛋白激酶的激活可以抑制胆固醇、脂肪的合成，最近研究表明，腺苷酸活化蛋白激酶的激活也可抑制胆汁酸合成及促进胆盐输出泵的生成，说明腺苷酸活化蛋白激酶在调节胆汁酸代谢中起着重要作用。本文将从腺苷酸活化蛋白激酶激活途径、胆汁酸代谢、腺苷酸活化蛋白激酶活性对胆汁酸合成及转运等方面进行综述。Adenosine monophosphate-activated protein kinase （AMPK） activation also can inhibit the synthesis of cholesterol and fat. Recent studies have shown that activation of AMPK can also inhibit the synthesis of bile acid and promote bile salt export pump＇ s generation. All of those illustrated that AMPK played an important role in reg- ulating bile acid metabolism. This article will summarize the AMPK activation pathway, bile acid metabolism, AMPK activity in bile acid synthesis and transfer, and so on.

关 键 词：腺苷酸活化蛋白激酶 胆汁酸类和盐类 胆盐输出泵 类固醇受体辅激活蛋白-2 瘦素 

分 类 号：R657.4[医药卫生—外科学]