2000～2011年金黄色葡萄球菌耐药性调查分析  

Drug Resistance Investigation of Staphylococcus aureus between 2000 and 2011

作　　者：王亚霞[1] 刘亚新[1] 高惠惠[1] 沈蓓琼[2] 

机构地区：[1]浙江省人民医院感染管理科,杭州310014 [2]浙江省人民医院微生物实验室,杭州310014

出　　处：《医药导报》2013年第1期26-28,共3页Herald of Medicine

摘　　要：目的调查2000～2011年某三甲医院金黄色葡萄球菌临床分离株的耐药性变化趋势,为临床医生抗感染治疗提供依据。方法采用VITEK-32全自动细菌分析系统,GPS-119G药敏分析卡,药敏琼脂(M-H)均为法国梅里埃公司产品。用头孢西丁纸片扩散法(K-B法)进行抗菌药物活性试验。结果该院耐甲氧西林金黄色葡萄球菌(MRSA)的耐药率在71.1%～87.4%,同期医院感染菌耐药率在44.8%～87.5%,变化无明显规律性。结论耐药菌多年来居高不下,需规范使用抗菌药物、落实消毒隔离措施和提高手卫生依从性。Objective To investigate the variation trend of drug resistance of the clinical isolated Staphylococcus aureus in a three A hospital during 2000-2011, and provide for clinicians the guidance of anti-infective therapy. Methods VITEK-32 automatic bacterial analysis system was applied with the GPS-119G drug susceptibility analysis card, drug sensitive testing agar （M-H） from Merieux France. The efficacy test of antibiotics was conducted with cefoxitin disk diffusion method （ K- B method）. Results The drug resistance rate of methicillin-resistant Staphylococcus aureus （MRSA） ranged t^om 71. 1% - 87.4% in the whole hospital, while that of the hospital infected bacteria was within 44.8%-87.5% over the same period and the change was irregular. Conclusion For a few years, the drug resistant bacteria keep high, it is necessary, to normalize antibiotics＂ application, carry out disinfection and quarantine measures, and improve hand hygiene compliance.

关 键 词：耐药性 耐甲氧西林金黄色葡萄球菌 金黄色葡萄球菌 

分 类 号：R978[医药卫生—药品]