痰菌不阴转肺结核的影响因素分析  

Analysis on non-negative result of sputum test in patients with pulmonary tuberculosis

作　　者：杜正新[1] 刘志辉[1] 蔡思勤[1] 罗少珍[1] 罗少霞[1] 

机构地区：[1]广州市胸科医院,510095

出　　处：《广州医药》2013年第1期3-5,共3页Guangzhou Medical Journal

基　　金：广东省科技厅项目(粤科函社字【2010】1096号)

摘　　要：目的探讨痰菌不阴转肺结核的相关因素,为结核病的科学防治提供依据。方法对我院2010年1月—2011年12月期间收治的109例规则治疗下痰菌不阴转肺结核病例及同时期治疗后痰菌阴转109例对照组的相关资料进行对比分析。结果痰菌未阴转组初治患者为71例(65.1%),复治患者38例(34.9%);而在阴转组,初治肺结核患者为88例(80.7%),复治21例(19.3%),差异有统计学意义(χ2=6.72,P=0.01)。未阴转组一线抗结核药物全药敏的有52例(54.2%),出现耐药的44例(45.8%),而在阴转组中全药敏65例(70.7%),耐药27例(29.3%),差异有统计学意义(χ2=5.43,P=0.02)。结论复治和耐药是痰菌不阴转的重要影响因素,应加强对结核病的科学防治,减少复治病患和耐药情况的出现。Objective To investigate relational factors of non-negative result of sputum test in patients with pulmonary tuberculosis and provide clues for the scientific prevention and treatment of tuberculosis. Methods Analyzed information from 109 cases and 109 controls who were consecutively recruited between January 2010 and December 2011. Results There were 71 patients of initial treatment and 38 patients of retreatment in the case group, which had significant difference from controls that with 88 patients of initial treatment and 21 patients of retreatment （χ2 = 6. 72, P = 0.01 ） . Similarly, there was statistically sig- nificant between cass and controls about first-line drug resistance, of which 52 drug susceptibility and 44 drug resistance in ea- ses, and 65 drug resistance and 27 of drug resistance in controls （χ2 = 5.43, P = 0. 02 ） . Conclusion Retreatment and drug resistance are important factors for patients with non-negative result in sputum test, and we should strengthen the prevention and treatment of tuberculosis to reduce the emergence of drug resistance.

关 键 词：痰菌不阴转 肺结核 一线药物 

分 类 号：R521[医药卫生—内科学]