微柱凝胶配血次侧凝集患者的免疫功能及红细胞输注疗效的探讨  

Study on the immune system of patients with hypo-side agglutination under micro-column gel agglutination assay blood matching and red blood cells transfusion efficacy

作　　者：冯红梅[1] 杨玉娟[2] 杨小榕[1] 马晓桂[1] 

机构地区：[1]广东药学院附属第一医院检验科,广州510080 [2]广州医学院附属口腔医院检验科,广州510140

出　　处：《广州医药》2013年第1期14-16,共3页Guangzhou Medical Journal

摘　　要：目的探讨微柱凝胶法配血次侧凝集患者的免疫功能及红细胞输注的临床疗效,为临床规范、科学、有效、合理的利用血液资源提供参考依据。方法对27例微柱凝胶法配血仅是次侧凝集而血型鉴定无误,抗筛阴性,自身对照阳性的患者,与35例同类型疾病但配血主次侧均相合的患者血清中的免疫球蛋白(IgG、IgA、IgM),补体(C3、C4)的含量进行比较,并评估红细胞输注的临床疗效。结果与对照组比较,微柱凝胶法配血次侧凝集患者的血清中免疫球蛋白IgG(12.19±3.063)mg/L、IgA(2.665±1.025)mg/L、IgM(0.836±0.499)mg/L的含量变化无统计学意义;而血清补体C3(0.739±0.306)mg/L,C4(0.209±0.096)mg/L则降低,有统计学意义(P<0.05)。27例患者共输血91次,其中无效输注43次,无效输注率47.25%。与对照组相比差异有统计学意义(P<0.05)。结论次侧凝集患者的免疫状态有改变,红细胞有效输注率低,输血需谨慎。Objective Exploring the immune system of patients with hypo-side agglutination using micro-column gel agglutination assay blood matching method and the efficacy of red blood cells transfusion, to provide clinical basis for scientifical- ly, effectively and rationally using of blood resources. Methods Comparing the contents of immunoglobulin （ IgG, IgA, IgM） and complement （ C3, CA） in the blood serum between 27 patients with hypo-side agglutination under micro-column gel aggluti- nation assay blood matching while their blood type identifieationswere correct, the anti-sieve negative and the self-comparison pos- itive, and 35 similar patients with both sides matching under blood match process, the clinical efficacy of their red blood cells transfusion was evaluated. Results Compared with the control group, micro-column gel agglutination patients with hypo-side agglutination ended up with IgG （12. 19 ± 3.063 ） mg/L , IgA （2. 665 ± 1. 025 ） mg/L, IgM （0. 836 ± 0. 499 ） mg/L was not statistically significant ; but their blood serum complement C3 （0. 739 ± 0. 306 ） mg/L, CA （ 0. 209 ± 0. 096 ） mg/L fell significantly , which was statistically significant （P 〈 0. 05 ） . On the other hand, the 27 patients took 91 transfusions which contained 43 invalided infusions, showed that the invalid rate was 47.25%, which was statistically significant （ P 〈 0. 05 ）, compared with the control group. Conclusion Hypo-side agglutination patients, immune systemshad been affected and red blood cells transfusion came up with a low successful rate. Transfusion need to be considered seriously.

关 键 词：微柱凝胶配血 次侧凝集 免疫球蛋白 补体 红细胞输注疗效 

分 类 号：R457.1[医药卫生—治疗学]