高血压病痰湿体质者炎性标志物改变的初步探讨  

Preliminary Study on Inflammatory Biomarkers Changes in Hypertensive Patients with Phlegm-dampness Constitution

作　　者：杨晓翠[1] 罗海明[2] 姚春梅[2] 朱岩峰[2] 

机构地区：[1]浙江省上虞市中医院 [2]上海中医药大学附属岳阳中西医结合医院

出　　处：《中西医结合心脑血管病杂志》2013年第1期1-3,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨高血压病人群痰湿体质易发心脑血管事件的病理生理学基础。方法观察比较高血压病人群中痰湿体质者与平和质者的炎性标志物高敏C反应蛋白(hs-CRP)、纤维蛋白原以及血脂各项指标、体重指数等水平的差异。结果痰湿体质组的hs-CRP明显高于平和体质组,且有统计学意义;而高密度脂蛋白水平低于平和体质组(1.03mmol/L±0.26mmol/L vs 1.15mmol/L±0.29mmol/L,P<0.05),其他血脂指标有差别趋势但未达统计学意义;痰湿体质组体重指数为(26.24±2.34)kg/m2,与平和质组(22.29±1.71)kg/m2比较有统计学意义。结论高血压病痰湿体质病人存在明显慢性炎症、血脂代谢异常、肥胖等类似代谢综合征的病理改变,是痰湿体质者更易发生动脉粥样硬化性心脑血管事件的原因之一。Objective To explore the pathophysiological basis of phlegm - dampness constitution who were susceptible to cardio- vascular and cerebrovascular event in hypertensive patients with phlegm - dampness constitution. Methods The difference of high - sensitivity C - reactive protein （hs -CRP）, blood lipid and body mass index（BMI） between phlegm -dampness constitution group and gentle constitution group were evaluated. Results The levels of hs - CRP in phlegm - dampness constitution group were higher than that in gentle constitution group. The levels of high -density lipoprotein cholesterol （HDL -C） in phlegm -dampness group were significantly lower than that in gentle group （1.03 mmol/L±0.26 mmol/L vs 1.15 mmol/L±0.29 mmol/L,P〈0.05）. BMI in Phlegmdampness constitution group was bigger than that in gentle constitution group（26.24 kg/m^2 ±2.34 kg/m^2 vs 22.29 kg/m^2 ± 1.71 kg/m^2 ,P〈0. 05）. Conclusion There were obvious inflammation change,lipid metabolism disorders and obesity in hypertensive patients with phlegm- dampness constitution, which was one of causes of susceptibility to cardiovascular and cerebrovascular event.

关 键 词：高血压病 痰湿体质 炎性标志物 脂质代谢 心脑血管事件 

分 类 号：R544.1[医药卫生—心血管疾病] R255.3[医药卫生—内科学]