基于粗糙集的肾气丸、右归丸、右归饮3首补肾阳类方配伍规律研究  

Study on the Law of Compatibility in Three Categorized Formulas for Tonifying Shen Yang: Shenqi Pill, Yougui Pill, and Yougui Drink based on Rough Set

作　　者：王秀凤[1] 伊丽娜 张磊[3] 李静[4] 罗来成[3] 

机构地区：[1]广东药学院基础学院数学部,广州510006 [2]江西中医学院基础医学院机能学科组,南昌330006 [3]广东药学院基础学院物理部,广州510006 [4]广东药学院基础学院生理学教研室,广州510006

出　　处：《中国中西医结合杂志》2013年第1期114-118,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.30973977)

摘　　要：目的用粗糙集的方法评价肾气丸、右归丸、右归饮3首补肾阳类方的疗效,探究其中的核心药和边缘药以及核心药中的补阴药和补阳药之间的配伍规律。方法把大鼠分为:正常组、肾阳虚模型组以及肾气丸、右归丸、右归饮3首补肾阳类方各自的原方组、核心药组和边缘药组,共11组。分别检测其四碘甲腺原氨酸(thyroxine,T4)、皮质醇(cortisol,CORT)、睾酮(testosterone,T)。建立基于粗糙集的决策规则模型,根据决策规则分析各药物之间的相互作用。结果山药分别与肉桂、附子及枸杞子有很好的协同作用;茯苓、牡丹皮和泽泻本身虽然没有效果,但均与肾气丸的核心药有协同作用;当归本身有一定的效果,对右归丸核心药的作用各不相同;甘草本身对提高药效没有效果,对右归饮的核心药均有拮抗作用。结论补肾阳类方核心药的配伍应注重阴阳并补、阴阳互济,同时要根据核心药的不同选择合适的边缘药与之配伍。所建基于粗糙集的决策规则模型在探讨类方配伍规律方面有良好的应用前景。Objective To evaluate the efficacy of three categorized formulas for tonifying Shen yang, i.e. Shenqi Pill （SP）, Yougui Pill （YP）, and Yougui Drink （YD）based on rough set, thus exploring the law of compatibility between the core herbs and the edge herbs as well as the law of compatibility between the yang-tonifying herbs and the yin-tonifying herbs in the core herbs. Methods The rats were divided into the normal group, the Shen-yang deficiency model group, and the original prescription group, the core herbs group, and the edge herbs group of this three categorized formulas for tonifying Shen yang, 11 groups altogether. Thyroxine （T4）, cortisol （CORT）, and testosterone （T）were detected respectively. The decision rules model based on rough set was set up, the interactions between various herbs were analyzed according to the decision rules. Results There were synergies between yam and cinnamon, yam and aconite, as well as yam and wolfberry. Poria alisma, Cortex Moutan, and oriental waterplantain tuber had no effect themselves, but they had synergistic effects with the core herbs in SP. Angelica had a certain effect itself, but its functions were different to different core herbs in YP. Licorice had no effect itself, and it was antagonistic with the core herbs in YD. Conclusions The compatibility of core herbs of categorized formula for tonifying Shen yang should focus on benefiting both yin and yang, as well as mutual rooting of yin-yang. Appropriate edge herbs should be chosen for compatibility according to different core herbs. The decision rules model based on rough set has a good prospect in exploring the law of compatibility of the categorized formulas.

关 键 词：肾阳虚 补肾阳类方 核心药 边缘药 粗糙集 决策规则 

分 类 号：R289[医药卫生—方剂学]