麻腮风联合减毒活疫苗渗透压摩尔浓度的分析  

Determination of osmolality of live attenuated measles,mumps and rubella combined vaccine

作　　者：丁锐[1] 纪宏[1] 胡琴[1] 陈思[1] 刘奕明[1] 周长明[1] 

机构地区：[1]北京市药品检验所,北京100035

出　　处：《中国生物制品学杂志》2013年第1期9-10,16,共3页Chinese Journal of Biologicals

摘　　要：目的分析麻腮风联合减毒活疫苗的渗透压摩尔浓度,为提高该疫苗的质量标准提供参考。方法按照《中国药典》三部(2010版)附录渗透压摩尔浓度测定法,采用冰点下降法测定市售31批麻腮风联合减毒活疫苗的渗透压摩尔浓度。结果 31批麻腮风联合减毒活疫苗的渗透压摩尔浓度存在一定差异,在620～774 mOsmol/kg之间。结论在麻腮风联合减毒活疫苗成品质量标准中增加渗透压摩尔浓度的检测十分必要。Objective To determine the osmolality of live attenuated measles,mumps and rubella combined vaccine,and provide a reference for improve the quality standard of the vaccine.Methods The osmolality of 31 batches of live attenuated measles,mumps and rubella combined vaccine were determined by freezing point osmometer according to requirements in Chinese Pharmacopoeia（Volume III,2010 edition）.Results The osmolality of 31 batches of vaccine ranged from 620 to 774 mOsmol / kg,which showed a certain difference.Conclusion It is necessary to include the determination of osmolality into the quality control of live attenuated measles,mumps and rubella combined vaccine.

关 键 词：麻腮风联合减毒活疫苗 渗透压摩尔浓度 

分 类 号：R373.11[医药卫生—病原生物学] R392.33[医药卫生—基础医学]