内蒙古包头地区汉族原发性高血压与HLA-DQA1*0301等位基因的相关性研究  

A study of correlation between essential hypertension and HLA-DQA1*0301 allele in the Hans of Baotou in Inner Mongolia

作　　者：李琴[1,2] 周俊红[2,3] 杨文杰[2] 秦文斌[2] 雎天林[2] 

机构地区：[1]中国环境科学研究院环境标准研究所,北京100012 [2]包头医学院基因诊断研究所,包头014010 [3]中关村医院口腔科,北京100080

出　　处：《安徽医科大学学报》2013年第2期146-149,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家重点基础研究发展计划项目(编号:2008CB418205);国家环保公益性行业科研专项(编号:200909101)

摘　　要：目的探讨内蒙古包头地区汉族人群中原发性高血压与人类白细胞抗原(HLA)-DQA1*0301等位基因的相关性。方法用聚合酶链反应-序列特异性引物(PCR-SSP)技术对原发性高血压患者119例(高血压组)及正常对照组130例进行HLA-DQA1*0301等位基因的检测,并对结果进行分组比较。结果 HLA-DQA1*0301等位基因频率在高血压组为0.403 4,正常对照组为0.376 9,两组频率差异无统计学意义。按性别及有无家族史分组统计HLA-DQA1*0301等位基因频率,各组间差异亦无统计学意义。采用Lo-gistic回归控制了年龄的混杂作用后分析HLA-DQA1*0301基因与高血压发生的关系,结果显示该基因与高血压的发生没有关系。结论内蒙古包头地区汉族人群原发性高血压与HLA-DQA1*0301等位基因可能无相关性。Objective To investigate the association of HLA-DQA1 ＊ 0301 allele and essential hypertension in the Hans of Baotou Inner Mongolia. Methods HLA-DQA1 ＊ 0301 allele was detected by PCR-SSP technic in 119 ca- ses of essential hypertensives and 130 normal individuals as the control. Results The frequencies of HLA-DQA1 ＊ 0301 allele in hypertensive group and control group were 0. 403 4 and 0. 376 9. There was no significant difference between the two groups （X2 =0. 183, P =0. 669）. The frequencies of HLA-DQA1 ＊ 0301 allele was analysed ac- cording to gender and family history, and there was also no significant difference. The results of Logistic regression analysis showed no statistical correlation between the HLA-DQA1 ＊ 0301 gene and hypertension after adjusting for potential confounding effects of age （ P = 0. 602）. Conclusion HLA-DQA1 ＊ 0301 allele may be not a correlative gene of essential hypertension in the Hans of Baotou Inner Mongolia.

关 键 词：原发性高血压 HLA—DQA1＊0301 聚合酶链反应-序列特异性引物 

分 类 号：R544.1[医药卫生—心血管疾病] R394.1[医药卫生—内科学]