129例自然妊娠与ART术后妊娠早期流产胎儿绒毛染色体核型分析  

Chromosome karyotype analysis for early abortion villi from 129 cases of natural and ART pregnancy

作　　者：郭楠[1] 刘雨生[1] 周桂香[1] 何国平[1] 宋雅娴[1] 

机构地区：[1]安徽医科大学附属省立医院生殖医学中心,合肥230001

出　　处：《安徽医科大学学报》2013年第2期163-166,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅医学科研项目(编号:09B115);安徽省立医院三新项目(编号:2010015)

摘　　要：目的探讨自然妊娠与辅助生殖技术(ART)术后妊娠早期流产的绒毛染色体核型分析结果差异及年龄、ART受精方式等因素对早期流产中绒毛染色体核型异常率的影响。方法排除内分泌、免疫、感染、解剖等因素对流产的影响,将48例自然妊娠(自然妊娠组)、81例ART术后妊娠(ART组)早期流产患者纳入研究对象,对自然妊娠组、ART组早期流产绒毛组织进行染色体核型分析,比较流产胚胎的染色体核型异常率的差异及观察年龄、ART受精方式对核型结果的影响。结果自然妊娠组流产胚胎染色体异常率43.75%,ART组流产胚胎染色体异常率59.26%,两组间染色体异常率比较差异无统计学意义。自然妊娠在35岁及以上人群(42.86%)与35岁以下人群(43.90%)间的流产胚胎染色体异常率比较无统计学意义,但ART组在35岁以上人群(80.56%)及35岁以下人群(42.22%)间的流产胚胎染色体异常率差异有统计学意义(P<0.05)。结论 ART术后妊娠早期流产与胚胎染色体异常密切相关,其染色体异常发生率与自然妊娠后早期流产无明显差异,与年龄相关,而与受精方式无关。Objective To explore the differences of early spontaneous abortion karyotype analysis between natural pregnancy and assisted reproductive technology （ART） group, then to discuss age, the ways of insemination on the impact of genetic factors in spontaneous abortion. Methods Excluding the influence of endocrine, immunity, infection, and anatomical factors on abortion, 48 cases of natural conception（ natural conception group） , 81 cases of the ART（ ART group） postoperative spontaneous abortion .were included in the study. According to the early spontaneous abortion karyotype analysis between natural pregnancy and ART groups, to compare the differences of abortion embryonic karyotype abnormality rate, furthernlore observe the age and ways of insemination impacting on results. Results The incidence of fetal chromosomal abnormalities in natural group and ART group were respectively 43.75% and 59.26% , and this difference was not statistically significant in the two groups. The incidence of fetal chromosomal abnormalities had no significant difference above the age of 35 and lower in natural group. But significant difference was found in ART group. Conclusion First trimester abortion after ART is closely related to fetal chromosomal abnormalities, but there was no significant different with natural group. And the incidence was difference with maternal age, and had nothing to do with the ways of insemination.

关 键 词：辅助生殖技术 自然妊娠 自然流产 绒毛 核型分析 

分 类 号：R714.21[医药卫生—妇产科学]