多囊卵巢综合征患者空腹血清Ghrelin水平变化及相关因素分析  

Changes of fasting serum Ghrelin and relative factors in patients with polycystic ovarian syndrome

作　　者：杜娟[1] 王长江[1] 胡红琳[1] 代芳[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,合肥230022

出　　处：《安徽医科大学学报》2013年第2期178-181,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学重点项目(编号:KJ2009 B047Z)

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者空腹血清Ghrelin水平变化及相关性因素。方法选取48例PCOS患者(PCOS组)和32名正常体检者(对照组),PCOS组按照体质指数(BMI)≥25 kg/m2或<25 kg/m2,又各自分为超重/肥胖(PCOSObesity)亚组和体重正常(PCOSLean)亚组。采用酶联免疫吸附法测定各组空腹血清Ghrelin水平,同时检测黄体生成素、卵泡刺激素、睾酮(T)、空腹血糖(FPG)和胰岛素(FINS)水平;测量身高、体质量、腰围(WC)、臀围;并计算BMI、腰臀比(WHR)、稳态模型胰岛素抵抗指数(HOMA-IR)和胰岛β细胞分泌功能(HOMA-β)。FINS、HOMA-IR、HO-MA-β经对数转化为FINSln、HOMA-IRln和HOMA-βln后符合正态分布。结果①PCOS组空腹血清Ghrelin水平低于对照组,PCOSObesity亚组空腹Ghrelin水平低于PCOSLean亚组(P<0.01);②Pearson相关分析显示,PCOS组空腹血清Ghre-lin水平与BMI、WC、WHR、FINSln、HOMA-IRln与HOMA-βln(r=-0.774、-0.649、-0.553、-0.590、-0.575、-0.431,P<0.01)呈负相关;③多元逐步回归分析显示,BMI是影响Ghrelin水平的独立相关因素。结论 Ghrelin水平降低可能是控制PCOS患者肥胖和胰岛素抵抗进一步发展的保护性因素。Objective To evaluate the variation of fasting serum ghrelin and relative factors in patients with poly- cystic ovarian syndrome（PCOS）. Methods 48 patients and 32 controls were selected and each group was divided into overweight/obese and non-obese subgroups according to body mass index （BMI） i〉25 kg/m2 or 〈25 kg/m2. The concentration of fasting serum ghrelin was assayed by ELISA. Meanwhile, fasting levels of luteinizing hormone （LH） , follicle stimulating hormone （FSH） , testosterone （T） , plasma glucose （FPG） and insulin （ FINS ） were also measured. Anthropometric measurement, BMI,waist-hip ratio（WHR） HOMA-IR and HOMA-B were also calculated . Results ①Fasting plasma ghrelin level was significantly lower in PCOS groups versus controls （P 〈0. 01 ） and overweight / obese subgroup was lower than non-obese subgroup （P 〈 0. 01）in PCOS ;② Fasting serum ghrelin level correlated negatively with BMI, WC, WHR, FINSln, HOMA-IRln, HOMA-B1n （ r = - 0. 774, - 0. 649, - 0. 553, -0. 590, -0. 575, -0. 431, P 〈0. 01）;③ Multiple stepwise regression analysis showed that BMI was the inde- pendent influential factor of serum ghrelin level. Conclusion Lower ghrelin level may be a protective factor in P- COS with obesity and insulin resistance.

关 键 词：多囊卵巢综合征 胃促生长素 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]