Antimycotic efficacy of Iranian medicinal plants towards dermatophytes obtained from patients with dermatophytosis  

作　　者：Ali Reza Khosravi Hojjatollah Shokri Zohreh Farahnejat Reza Chalangari Martis Katalin 

机构地区：[1]Mycology Research Center, Faculty of Veterinary Medicine University of Tehran, Tehran, lran [2]Faculty of Veterinary Medicine, University of Mazandaran, Amol, lran [3]Department of Medical Mycology and Parasitology, Artesh University of Medical Sciences, Tehran, lran [4]Dermatology Clinic, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, lran

出　　处：《中国天然药物》2013年第1期43-48,共6页

基　　金：supported by the Council for Research of the University of Tehran,Iran

摘　　要：从 Artemisia sieberi， Cuminum cyminum， Foeniculum vulgare， Heracleum persicum， Menta spicata， Nigella sativa， Rosmarinus officinalis， Zataria multiflora 和 Ziziphora 瞄准九植物香精油(曙光女神) ，包括那些 clinopodioides，为他们的 anti-dermatophytic 性质被评估。测试皮藓菌包括了 Trichophyton mentagrophytes (号码 32 ) 的方法， T。rubrum (号码 29 ) ， Epidermophyton floccosum (号码 19 ) ， Microsporum gypseum (号码 11 ) 和 M。canis (号码 42 ) 。植物油的危险性测试被由临床的实验室标准协会描述了的肉汤 microdilution 技术以最小的禁止的集中(MIC ) 和最小的杀菌剂集中(MFC ) 执行。所有曙光女神学习了的结果对皮藓菌是活跃的。MIC 为测试的植物油记录了从 0.25 ～ 4 mg ‰ ? 娠潨杮潺杮?? € 楑 ???????????? 丠??? ? ㈠吗？？AIM： Nine plant essential oils （EOs）, including those from Artemisia sieberi, Cuminum cyminum, Foeniculum vulgare, Heracleum persicum, Menta spicata, Nigella sativa, Rosmarinus officinalis, Zataria multiflora and Ziziphora clinopodioides, were evaluated for their anti-dermatophytic properties. METHODS： The tested dermatophytes included Trichophyton mentagrophytes （No. 32）, T. rubrum （No. 29）, Epidermophyton floccosum （No. 19）, Microsporum gypseum （No. 11） and M. canis （No. 42）. The susceptibil- ity tests of plant oils in terms of minimal inhibitory concentration （MIC） and minimal fungicidal concentration （MFC） were performed by the broth microdilution technique as described by the Clinical Laboratory Standard Institute. RESULTS： All EOs studied were active against the dermatophytes. The MICs recorded for the plant oils tested ranged from 0.25 to 4 mg·mL^-1. The most significant activity was observed with A. sieberi, showing a lower MIC against dermatophytes than other plant oils （P 〈 0.05）. CONCLUSION： Data from this study indicated that several Iranian medicinal plant oils, mainly A. sieberi, are active in vitro against different dermato- phyte species, suggesting their potential use for the topical treatment of dermatophytoses.

关 键 词：Antifungal activity Iranian herbal plants Artemisia sieberi Essential oil Dermatophytes. 

分 类 号：R965[医药卫生—药理学]