依地酸钠钙治疗儿童铅中毒的临床疗效观察  

Clinical Effectiveness of CaNa_2EDTA Treatment in Children with Lead Poisoning

作　　者：李颖 肖雄斌 张晓华 袁娟 

机构地区：[1]湖南省职业病防治院,湖南长沙410007

出　　处：《环境与职业医学》2013年第1期61-62,共2页Journal of Environmental and Occupational Medicine

摘　　要：[目的]探讨依地酸钠钙(CaNa2EDTA)治疗儿童慢性铅中毒的疗效及其安全性。[方法]对医院2006—2008年收治的60名中重度铅中毒儿童患者用CaNa2EDTA静脉滴注进行驱铅治疗,比较治疗前后的血铅变化,并观察其不良反应和副作用。[结果]60例中重度铅中毒患儿中,血铅平均浓度≥700μg/L者9例,450～700μg/L者29例,250～449μg/L者22例。治疗前血铅平均浓度分别为(881.76±141.03)、(545.47±51.54)、(389.07±39.49)μg/L。予以1个疗程CaNa2EDTA治疗后明显下降,血铅平均浓度分别为(585.78±115.17)、(356.97±27.3)、(213.23±37.09)μg/L。治疗期间无1例出现不良反应,复查相关项目未见异常。[结论]采用CaNa2EDTA静脉滴注治疗儿童中重度铅中毒,疗效显著,用药较安全。[ Objective ] To explore the effectiveness and safety of calcium disodium edetate （CaNa2EDTA） intravenous drip administration on childhood chronic lead poisoning. [ Methods ] Sixty children with moderate to severe lead poisoning were admitted to a hospital and treated by CaNa2EDTA intravenous drip administration between 2006 and 2008. Blood lead levels before and after the treatment were recorded and compared. The children were observed for any side effects or abnormality related to the treatment. [ Results ] Of the 60 patients studied, 9 cases had their blood lead level ~ 700 ~g/L, 29 cases in the range of 450-700 p,g/L, and 22 cases between 250-449 pg/L. The average blood lead levels before treatment of the 3 blood-lead-level groups were （881.76 ± 141.03）μg/L, （545.47 ±51.54）μg/L, and （389.07 ＋ 39.49）μg/L, respectively. After a course of treatment, the average concentrations of blood lead were （585.78 ± 115.17）μg/L, （356.97 ± 27.3）μg/L, and （213.23 ± 37.09）μg/L, respectively. No related abnormality or side effect was observed during the treatment or hospital review. [ Conclusion ] CaNa2EDTA intravenous drip administration has been proved safe and effective in treating children moderate to severe lead poisoning.

关 键 词：儿童 铅中毒 依地酸钠钙 

分 类 号：R453[医药卫生—治疗学]